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Details for messenger / hormone: SECTM1

EndoNet ID: ENH00643

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Synonyms

  • SECTM1
  • secreted and transmembrane protein 1
  • protein K12
  • K12

General information

  • Golgi-associated protein with transmembrane and secreted isoforms. [1]
  • K12, an epithelial cell secreted protein, was identified as a CD7 ligand. [2]
  • K12 is produced by human thymic epithelial cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma. [2]
  • A 20-kDa soluble form of the K12 protein derived from the N-terminal domain is secreted. [1]
  • Function: K12 might be involved in thymocyte signalling and cytokine release, and is regulated by IFN-gamma. [2]

Classification

Hormone function

  • homeostasis
    • further hormone secretion
    • immune response

    Chemical classification

    Composition

    Secreted and transmembrane protein 1 (chain).

    Sequence 
    QNEGWDSPI CTEGVVSVS WGENTVMSC 
NISNAFSHV NIKLRAHGQ ESAIFNEVA 
PGYFSRDGW QLQVQGGVA QLVIKGARD 
SHAGLYMWH LVGHQRNNR QVTLEVSGA 
EPQSAPDTG FWPVPAVVT AVFILLVAL 
VMFAWYRCR CSQQRREKK FFLLEPQMK 
VAALRAGAQ QGLSRASAE LWTPDSEPT 
PRPLALVFK PSPLGALEL LSPQPLFPY 
AADP
    UniProt Q8WVN6

    Links to other resources

    UniProt Q8WVN6
    Ensembl ENST00000269389
    KEGG hsa:6398

    • Anatomical structure: peripheral blood leukocytes

    • Anatomical structure: neutrophil_granulocyte

    • Anatomical structure: thymus

    • Anatomical structure: thymocyte

    Targets

    Cell
    No records found.
    Reference