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Details for messenger / hormone: FGF-16

EndoNet ID: ENH00652

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Synonyms

  • FGF-16
  • fibroblast growth factor 16
  • FGF16
  • FGFG

General information

  • Induces hepatocellular proliferation.
  • Involved in central nervous system development.

Classification

Hormone function

  • development and growth
    • growth stimulation
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • heparin-binding growth factors

        Composition

        Sequence
        MAEVGGVFA SLDWDLHGF SSSLGNVPL 
        ADSPGFLNE RLGQIEGKL QRGSPTDFA 
        HLKGILRRR QLYCRTGFH LEIFPNGTV 
        HGTRHDHSR FGILEFISL AVGLISIRG 
        VDSGLYLGM NERGELYGS KKLTRECVF 
        REQFEENWY NTYASTLYK HSDSERQYY 
        VALNKDGSP REGYRTKRH QKFTHFLPR 
        PVDPSKLPS MSRDLFHYR

        Links to other resources

        UniProt O43320
        KEGG hsa:8823
        • Anatomical structure: endocardium

          • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium and endocardium of the midgestation mouse heart. [1]
        • Anatomical structure: pericardium

          • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium (inner layer of pericardium) and endocardium of the midgestation mouse heart. [1]

        Targets

        CellFGFR-1FGFR-2FGFR-3
        adrenal cortex Present
        Present
        brain Present
        Phenotypes
        • Kallmann syndrome 2
        • olfactory bulb morphogenesis
        cardiac muscle Present
        Phenotypes
        • regulation of cell proliferation
        Present
        Phenotypes
        • regulation of cell proliferation
        cerebral cortex Present
        Phenotypes
        • regulation of neuron differentiation
        chondrocyte Present
        Present
        Phenotypes
        • endochondral ossification
        endocardium Present
        Reference