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Details for messenger / hormone: FGF-18

EndoNet ID: ENH00654

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Synonyms

  • FGF-18
  • fibroblast growth factor 18
  • zFGF5
  • FGF18
  • FGFI

General information

  • FGF-18 is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. [1]
  • FGF18 represses noggin expression and is induced by calcineurin. [2]
  • FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. [3]
  • The decreased FGF-18 expression and elastic fiber deposition cause the impaired septation in congenital diaphragmatic hernia (CDH). [4]
  • Essential regulator of long bone and calvarial development.

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      Sequence
      EENVDFRIH VENQTRARD DVSRKQLRL 
      YQLYSRTSG KHIQVLGRR ISARGEDGD 
      KYAQLLVET DTFGSQVRI KGKETEFYL 
      CMNRKGKLV GKPDGTSKE CVFIEKVLE 
      NNYTALMSA KYSGWYVGF TKKGRPRKG 
      PKTRENQQD VHFMKRYPK GQPELQKPF 
      KYTTVTKRS RRIRPTHPA

      Links to other resources

      UniProt O76093
      Ensembl ENST00000274625
      KEGG hsa:8817
      • Anatomical structure: sinusoidal_endothelial_cell

        • FGF18 expression was detected in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. [5]

      Targets

      CellFGFR-4
      hepatocyte Present
      Reference