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Details for messenger / hormone: FGF-20

EndoNet ID: ENH00655

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Synonyms

  • FGF-20
  • fibroblast growth factor 20
  • FGF20
  • FGFK

General information

  • Neurotrophic factor that regulates central nervous development and function. [1]
  • FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. [2]
  • FGF20 is a neurotrophic factor widely expressed in dopaminergic neurons of the substantia nigra pars compacta, and enhances the survival of midbrain dopaminergic neurons. [3]
  • FGF20 is up-regulated in colorectal cancer due to the activation of WNT/beta-catenin pathway. [4]
  • FGF-20 promotes the differentiation of Nurr1-NSCs into tyrosine hydroxylase-positive neurons. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • heparin-binding growth factors

        Composition

        Sequence
        MAPLAEVGG FLGGLEGLG QQVGSHFLL 
        PPAGERPPL LGERRSAAE RSARGGPGA 
        AQLAHLHGI LRRRQLYCR TGFHLQILP 
        DGSVQGTRQ DHSLFGILE FISVAVGLV 
        SIRGVDSGL YLGMNDKGE LYGSEKLTS 
        ECIFREQFE ENWYNTYSS NIYKHGDTG 
        RRYFVALNK DGTPRDGAR SKRHQKFTH 
        FLPRPVDPE RVPELYKDL LMYT

        Links to other resources

        UniProt Q9NP95
        Ensembl ENST00000180166
        KEGG hsa:26281
        • Anatomical structure: cerebellum

        • Anatomical structure: endocardium

          • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium and endocardium of the midgestation mouse heart. [6]
        • Anatomical structure: pericardium

          • Here, we demonstrate specific expression of Fgf9, Fgf16, and Fgf20 in the epicardium (inner layer of pericardium) and endocardium of the midgestation mouse heart. [6]

        Targets

        CellFGFR-1FGFR-2FGFR-3
        adrenal cortex Present
        Present
        brain Present
        Phenotypes
        • Kallmann syndrome 2
        • olfactory bulb morphogenesis
        cardiac muscle Present
        Phenotypes
        • regulation of cell proliferation
        Present
        Phenotypes
        • regulation of cell proliferation
        cerebral cortex Present
        Phenotypes
        • regulation of neuron differentiation
        chondrocyte Present
        Present
        Phenotypes
        • endochondral ossification
        endocardium Present
        Reference