Status
Please wait ...

Details for messenger / hormone: AGR2

EndoNet ID: ENH00660

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • AGR2
  • anterior gradient protein 2 homolog
  • secreted cement gland protein XAG-2 homolog
  • AG-2 protein
  • hAG-2
  • HPC8
  • AG2
  • anterior gradient protein-2

General information

  • AGR2 is an androgen-inducible secretory protein overexpressed in prostate cancer. [1]
  • Interacts with LYPD3 and alpha-dystroglycan. [2]
  • hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. [3]
  • AGR2 is inducible by oestrogen and itself can induce metastasis in a rat model for breast cancer. [4]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Composition

    AGR2

    Sequence 
    RDTTVKPGA KKDTKDSRP KLPQTLSRG 
WGDQLIWTQ TYEEALYKS KTSNKPLMI 
IHHLDECPH SQALKKVFA ENKEIQKLA 
EQFVLLNLV YETTDKHLS PDGQYVPRI 
MFVDPSLTV RADITGRYS NRLYAYEPA 
DTALLLDNM KKALKLLKT EL
    UniProt O95994

    Links to other resources

    UniProt O95994
    Ensembl ENST00000419572
    KEGG hsa:10551

    • Anatomical structure: epithelial_cell

    • Anatomical structure: small_intestine

    • Anatomical structure: colon

    • Anatomical structure: lung

    • Anatomical structure: stomach

    • Anatomical structure: prostate

    Targets

    Cell
    No records found.
    Reference