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Details for messenger / hormone: leukocystatin

EndoNet ID: ENH00663

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Synonyms

  • Cystatin-F
  • CST7
  • leukocystatin
  • cystatin F
  • cystatin-7
  • cystatin-like metastasis-associated protein
  • CMAP

General information

  • May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. [1]
  • Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor. [2]
  • Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. [3]
  • Cystatin F/CMAP seems to act in an opposite direction to cystatin E/M, promoting rather than suppressing metastasis to the liver. [4]
  • Leukocystatin is a class II cystatin expressed selectively by hematopoietic cells. [1]
  • High expression levels of CMAP were also identified as the strongest independent factor for liver metastasis. [4]

Classification

Hormone function

  • immune response

Chemical classification

Composition

Cystatin F

Sequence 
GPSPDTCSQ DLNSRVKPG FPKTIKTND 
PGVLQAARY SVEKFNNCT NDMFLFKES 
RITRALVQI VKGLKYMLE VEIGRTTCK 
KNQHLRLDD CDFQTNHTL KQTLSCYSE 
VWVVPWLQH FEVPVLRCH
UniProt O76096

Links to other resources

UniProt O76096
Ensembl ENST00000480798
KEGG hsa:8530

  • Anatomical structure: blood

  • Anatomical structure: spleen

  • Anatomical structure: peripheral blood leukocytes

  • Anatomical structure: thymus

  • Anatomical structure: small_intestine

  • Anatomical structure: immune_system

Targets

Cell
No records found.
Reference