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Details for messenger / hormone: CST6

EndoNet ID: ENH00664

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Synonyms

  • Cystatin-E
  • Cystatin-6
  • Cystatin-M
  • cystatin 6
  • CST6
  • cystatin E
  • cystatin M

General information

  • CST6 is a glycosylated and secreted cysteine protease inhibitor. [1]
  • Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site, and may have a role in epidermal cornification. [2]
  • Cystatin M/E is a high affinity inhibitor of the asparaginyl endopeptidase legumain. [2]
  • Ectopic expression of CST6 in human breast cancer cells suppresses cell proliferation, migration, invasion, and orthotopic tumor growth. [3]
  • Cystatin M is a tumor suppressor important in breast malignancy, and is a target for epigenetic silencing during mammary tumorigenesis. [4]
  • CST6 is a substrate for transglutaminase. [5]
  • CST6 alters the gene expression profile of human breast carcinoma cells, and down-regulates the potent mitogenic, motogenic, and angiogenic factor autotaxin. [3]
  • CST6 is down-regulated in breast cancer. [1]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    Cystatin M mature peptide.

    Sequence 
    RPQERMVGE LRDLSPDDP QVQKAAQAA 
VASYNMGSN SIYYFRDTH IIKAQSQLV 
AGIKYFLTM EMGSTDCRK TRVTGDHVD 
LTTCPLAAG AQQEKLRCD FEVLVVPWQ 
NSSQLLKHN CVQM

    Links to other resources

    UniProt Q15828
    Ensembl ENST00000312134
    KEGG hsa:1474

    • Anatomical structure: skin

    • Anatomical structure: sweat_glands

    • Anatomical structure: stratum_granulosum

      • In normal, nonpalmoplantar skin, cystatin M/E is highly expressed in the stratum granulosum. [6]
      • Cystatin M/E is constitutively expressed in the stratum granulosum of normal skin, sebaceous glands, eccrine sweat glands and the infundibular epithelium of hair follicles. [5]

    • Anatomical structure: mammary_gland

      • Cystatin M is expressed by normal mammary cells and a variety of human tissues. [1]

    • Anatomical structure: hair_follicle

    • Anatomical structure: sebaceous_glands

      • Cystatin M/E is constitutively expressed in the stratum granulosum of normal skin, sebaceous glands, eccrine sweat glands and the infundibular epithelium of hair follicles. [5]

    • Anatomical structure: keratinocyte

    Targets

    Cell
    No records found.
    Reference