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Details for messenger / hormone: LFA-3

EndoNet ID: ENH00668

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Synonyms

  • surface glycoprotein LFA-3
  • LFA-3
  • lymphocyte function-associated antigen 3
  • ag3
  • CD58 antigen
  • sCD58

General information

  • The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein. [1]
  • LFA-3 (CD58) mediates T-lymphocyte adhesion in chronic inflammatory infiltrates. [2]
  • The lymphocyte associated antigen 3 (LFA-3, CD58) has been found in soluble form (sCD58) in human sera. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • immunoglobulin superfamily

      Composition

      long isoform

      Sequence 
      FSQQIYGVV YGNVTFHVP SNVPLKEVL 
WKKQKDKVA ELENSEFRA FSSFKNRVY 
LDTVSGSLT IYNLTSSDE DEYEMESPN 
ITDTMKFFL YVLESLPSP TLTCALTNG 
SIEVQCMIP EHYNSHRGL IMYSWDCPM 
EQCKRNSTS IYFKMENDL PQKIQCTLS 
NPLFNTTSS IILTTCIPS SGHSRHRYA 
LIPIPLAVI TTCIVLYMN
      UniProt P19256-1

      Links to other resources

      UniProt P19256
      Ensembl ENST00000457047

      • Anatomical structure: leukocyte

        • The widespread, but not ubiquitous, distribution of LFA-3 contrasted with the more restricted distribution of ICAM-1. [4]
        • LFA-3 is widely distributed on peripheral blood leucocytes. [4]

      • Anatomical structure: cardiac_muscle

        • Furthermore, the unexpected finding that LFA-3 is strongly expressed on intercalated discs of cardiac muscle may possibly be related to a non-immune function, or indicate a structurally similar epitope expressed by an unrelated molecule within this tissue. [4]

      • Anatomical structure: thymic_epithelial_cell

        • In vitro studies suggest that intrathymic T-cell activation is mediated through binding between CD2 receptor on the thymocyte surface and LFA-3 expressed on thymic epithelium, particulary in the thymic subcapsular cortex. [4]

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

        • The presence of LFA-3 on dendritic cells is consistent with the specialised function of these cells in presenting antigen to effector T-cells. [4]

      Targets

      CellCD2
      T-lymphocyte Present
      Reference