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Details for messenger / hormone: PD-L2

EndoNet ID: ENH00670

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Synonyms

  • PD-L2
  • programmed cell death 1 ligand 2
  • programmed death ligand 2
  • PDCD1 ligand 2
  • butyrophilin B7-DC
  • CD273 antigen
  • PD-1 ligand 2
  • B7-DC

General information

  • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. [1]
  • B7-H1 and B7-DC play a role in virus-associated immune responses in the airways. [2]

Classification

Hormone function

  • immune response

Chemical classification

  • hormone
    • genome-encoded
      • immunoglobulin superfamily

    Composition

    PD-L2I, Type I

    Sequence
    LFTVTVPKE LYIIEHGSN VTLECNFDT 
    GSHVNLGAI TASLQKVEN DTSPHRERA 
    TLLEEQLPL GKASFHIPQ VQVRDEGQY 
    QCIIIYGVA WDYKYLTLK VKASYRKIN 
    THILKVPET DEVELTCQA TGYPLAEVS 
    WPNVSVPAN TSHSRTPEG LYQVTSVLR 
    LKPPPGRNF SCVFWNTHV RELTLASID 
    LQSQMEPRT HPTWLLHIF IPFCIIAFI 
    FIATVIALR KQLCQKLYS SKDTTKRPV 
    TTTKREVNS AI
    UniProt Q9BQ51-1

    Links to other resources

    UniProt Q9BQ51
    Ensembl ENST00000397747
    KEGG hsa:80380
    • Anatomical structure: sinusoidal_endothelial_cell

    Targets

    CellProgrammed cell death protein 1
    B-lymphocyte Present
    Phenotypes
    • Supression of autoreactive B-lymphocytes
    Reference