Please wait ...

Details for messenger / hormone: uteroglobin

EndoNet ID: ENH00671

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • uteroglobin
  • secretoglobin family 1A member 1
  • clara cell phospholipid-binding protein
  • clara cells 10 kDa secretory protein
  • CC10
  • urinary protein 1
  • urine protein 1
  • UP1
  • SCGB1A1
  • CCSP
  • UGB
  • UG
  • blastokinin
  • CC16
  • polychlorobiphenyl binding protein

General information

  • UG binds progesterone, polychlorinated biphenyls, and retinols. [1]
  • Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. [2]
  • UG has potent antiinflammatory and immunomodulatory properties. [1]
  • Homodimeric protein in which the 70 amino acids subunits are connected by two disulfide bonds in an antiparallel orientation. [1]
  • UG shows potent anti-inflammatory activity and inhibitory effects on neutrophil migration, thrombin-induced platelet aggregation, in vitro chemoinvasion, as well as "tumor suppressor"-like effects and other properties. [3]
  • UG is a potent inhibitor of PLA2 activity. [1]
  • Unusually small, spheric uterine secretory molecule without any carbohydrates. [4]
  • UG is normally expressed by most cells of epithelial origin but is known to be lost during the progression of prostate, lung, and uterine cancers to invasive malignancy. [5]
  • Progesterone-dependent secretion of uteroglobin is dose-dependent. [4]
  • IFN-gamma treatment of human bronchial cells induces expression of UG, and the production and biological activity of IFN-gamma are inhibited by UG. [1]
  • Inhibits both chemotaxis and phagocytosis of monocytes and neutrophils. [1]
  • Regulated by estrogen and progesterone in the female reproductive tract, by androgens in the male reproductive tract, by glucocorticoids, IFN-gamma, interleukin-4 and hyperoxia in the lungs. [6]
  • Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. [7]
  • UG has anti-proliferative and anti-metastatic effects in cancer cells. [8]
  • Uteroglobin suppresses SCCA gene expression associated with allergic asthma. [9]
  • UG expression is regulated by progestins, glucocorticoids, androgens, prolactin, and most likely other hormones and cytokines. [3]


Hormone function

  • development and growth
    • growth inhibition
    • immune response
      • inhibition

      Chemical classification


      uteroglobin (2 times)

      UniProt P11684

      Links to other resources

      UniProt P11684
      Ensembl ENST00000278282
      KEGG hsa:7356
      • Anatomical structure: uterus

      • Anatomical structure: epididymis

      • Anatomical structure: lung

      • Anatomical structure: cell_of_endometrium_of_uterus

      • Anatomical structure: thymus

      • Anatomical structure: digestive_system

      • Anatomical structure: pancreas

      • Anatomical structure: mammary_gland

      • Anatomical structure: prostate

      • Anatomical structure: epithelial_cell

      • Anatomical structure: pituitary_gland_of_diencephalon


      No records found.