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Details for messenger / hormone: BMP-15

EndoNet ID: ENH00679

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Synonyms

  • bone morphogenetic protein 15
  • growth/differentiation factor 9B
  • ODG2
  • BMP-15
  • BMP15
  • GDF-9B
  • GDF9B

General information

  • Missense mutations in the BMP15 gene are associated with ovarian failure. [1]
  • Oocyte-specific factor that regulates granulosa cell proliferation and differentiation, and is essential for normal follicular growth.
  • The expression of BMP-15 in breast cancer has an inhibitory effect on the progression of human breast cancer. [2]
  • The oocyte factor, bone morphogenetic protein-15 (BMP-15) has proven to be critical for normal fertility in female mammals. [3]
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [4]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Links to other resources

    UniProt O95972
    Ensembl ENST00000252677
    KEGG hsa:9210

    • Anatomical structure: ovary

    Targets

    Cell
    No records found.
    Reference