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Details for messenger / hormone: GDF-3

EndoNet ID: ENH00681

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Synonyms

  • growth/differentiation factor 3
  • growth differentiation factor 3
  • GDF-3
  • GDF3
  • Vgr-2
  • Vgr2

General information

  • Gdf3 acts in a Nodal-like signaling pathway in pre-gastrulation development.
  • GDF-3 is a non-diabetic adipogenic factor tightly coupled with fat metabolism. [1]
  • GDF-3 is structurally a bone morphogenetic protein/growth differentiation factor subfamily member of the TGF-beta superfamily. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      growth differentiation factor 3

      Sequence 
      AAIPVPKLS CKNLCHRHQ LFINFRDLG 
WHKWIIAPK GFMANYCHG ECPFSLTIS 
LNSSNYAFM QALMHAVDP EIPQAVCIP 
TKLSPISML YQDNNDNVI LRHYEDMVV 
DECGCG

      Links to other resources

      UniProt Q9NR23
      Ensembl ENST00000329913
      KEGG hsa:9573

      • Anatomical structure: bone_marrow

      • Anatomical structure: spleen

      • Anatomical structure: thymus

      • Anatomical structure: adipose_tissue

      Targets

      CellALK4ALK7
      adipose tissue Present
      Phenotypes
      • regulation of adipose-tissue homeostasis
      cell of endometrium of uterus Present
      Reference