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Details for messenger / hormone: big dynorphin

EndoNet ID: ENH00685

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Synonyms

  • big dynorphin
  • big Dyn

General information

  • 32-amino acid prodynorphin-derived peptide consisting of Dyn A and Dyn B. [1]
  • The presence in the brain implies that Big Dyn, along with other dynorphins, is processed from prodynorphin and secreted from neurons. [1]
  • Big Dyn differs from its fragments dynorphins A and B in its unique pattern of memory enhancing, locomotor- and anxiolytic-like effects that are sensitive to the NMDA receptor blockade. [2]
  • Interacts with human KOR, mu- (hMOR) and delta- (hDOR) opioid receptors and opioid receptor-like receptor 1 (hORL1). [1]
  • In its potency and selectivity to activate G proteins through KOR, and also in its profile of behavioural effects mediated through the NMDA receptors, Big Dyn differs from its degradation/conversion products Dyn A and Dyn B. [1]
  • These facts suggest that endogenous Big Dyn has its own function in the CNS that may be up-regulated when higher levels of activation of the KOR and/or NMDA receptors are required. [1]

Classification

Hormone function

Chemical classification

  • hormone
    • genome-encoded
      • peptide neurotransmitters
        • opioid neuropeptides

    Composition

    precursor Proenkephalin-B

    Sequence 
    MAWQGLVLA ACLLMFPST TADCLSRCS 
LCAVKTQDG PKPINPLIC SLQCQAALL 
PSEEWERCQ SFLSFFTPS TLGLNDKED 
LGSKSVGEG PYSELAKLS GSFLKELEK 
SKFLPSIST KENTLSKSL EEKLRGLSD 
GFREGAESE LMRDAQLND GAMETGTLY 
LAEEDPKEQ VKRYGGFLR KYPKRSSEV 
AGEGDGDSM GHEDLYKRY GGFLRRIRP 
KLKWDNQKR YGGFLRRQF KVVTRSQED 
PNAYSGELF DA

    Big dynorphin

    Sequence 
    YGGFLRRIR PKLKWDNQK RYGGFLRRQ 
FKVVT

    Links to other resources

    UniProt P01213

    • Anatomical structure: brain

      • Dynorphins are produced in several brain areas, including the basal ganglia, striatum, hippocampus, cerebral cortex, and spinal cord. [1]
      • Big Dyn was identified in the pituitary gland and brain as an abundant prodynorphin-derived peptide. [1]

    • Anatomical structure: pituitary_gland_of_diencephalon

      • Big Dyn was identified in the pituitary gland and brain as an abundant prodynorphin-derived peptide. [1]

    Targets

    Reference