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Details for messenger / hormone: metastin

EndoNet ID: ENH00686

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Synonyms

  • metastin
  • metastasis-suppressor KiSS-1
  • KISS1
  • KiSS-1 metastasis-suppressor
  • KiSS-1
  • kisspeptin-1
  • kisspeptin-54

General information

  • Metastin is secreted from the placenta throughout gestation, has been localized in syncytiotrophoblasts, and the C terminal decapeptide has been shown to inhibit trophoblast migration and invasion. [1]
  • Metastin and its variant forms suppress migration of pancreatic cancer cells. [2]
  • Provokes GnRH release and modulates the timing of puberty. [1]
  • Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. [3]
  • Initially characterized as a metastasis inhibitor, investigations using ligand/receptor pairing revealed that metastin was involved in a variety of physiological processes, including endocrine function during pregnancy and gonad development. [4]

Classification

Hormone function

  • development and growth
    • embryogenesis
    • reproduction and sexual differentiation
      • sexual differentiation

      Chemical classification

      • hormone
        • genome-encoded
          • kisspeptin family

        Composition

        metastin

        Sequence
        GTSLSPPPE SSGSRQQPG LSAPHSRQI 
        PAPQGAVLV QREKDLPNY NWNSFGLRF
        UniProt Q15726

        Links to other resources

        UniProt Q15726
        Ensembl ENST00000306118
        KEGG hsa:3814
        • Anatomical structure: anterior_periventricular_nucleus

          • In the anteroventral periventricular nucleus (AVPV), Sex steroids induce the expression of KiSS-1 [5]
        • Anatomical structure: arcuate_nucleus_of_hypothalamus

          • Kisspeptin is expressed abundantly in the arcuate nucleus (Arc) and the anteroventral periventricular nucleus (AVPV) of the forebrain. [6]

          Influenced by:

          • ER-alpha
            in arcuate_nucleus_of_hypothalamus
            • Estradiol and testosterone down-regulate Kiss1 mRNA in the Arc. [6]
          • ER-beta
            in arcuate_nucleus_of_hypothalamus
            • Estradiol and testosterone down-regulate Kiss1 mRNA in the Arc. [6]
          • unspecified testosterone receptor 1
            in arcuate_nucleus_of_hypothalamus
            • Estradiol and testosterone down-regulate Kiss1 mRNA in the Arc. [6]

        Targets

        CellGPR54
        cerebellum Present
        gonadotropin releasing hormone neuron Present
        Influences
        • GnRH-I
        Reference