Status
Please wait ...

Details for messenger / hormone: kisspeptin-10

EndoNet ID: ENH00687

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • Kisspeptin-54
  • Kisspeptin-1
  • metastasis-suppressor KiSS-1
  • kisspeptin-10
  • Kp-10
  • metastin (45-54)

General information

  • Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4. [1]
  • Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. [2]
  • The short-chain C-terminal decapeptide amide, metastin (45-54) (kisspeptin-10), exerts the identical bioactivities to metastin, such as metastasis suppression of cancer cells and inhibition of trophoblast migration and invasion. [3]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Kisspeptin-10

    Sequence 
    YNWNSFGLR F
    UniProt Q15726

    Links to other resources

    UniProt Q15726
    Ensembl ENST00000306118
    KEGG hsa:3814

      Targets

      CellGPR54
      cerebellum Present
      gonadotropin releasing hormone neuron Present
      Influences
      • ↑ GnRH-I
      Reference