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Details for messenger / hormone: chemerin

EndoNet ID: ENH00688

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Synonyms

  • RAR-responsive protein TIG2
  • chemerin
  • retinoic acid receptor responder 2
  • tazarotene-induced gene-2
  • TIG2
  • retinoic acid receptor responder protein 2
  • tazarotene-induced gene 2 protein
  • RARRES2

General information

  • Serine proteases factor XIIa and plasmin of the coagulation and fibrinolytic cascades, elastase and cathepsin G released from activated neutrophil granules and mast cell tryptase are all potent activators of chemerin. Activation results from cleavage of the labile carboxyl terminus of the chemoattractant at any of several different sites. [1]
  • Chemerin, first described as TIG2, is upregulated in tazarotene-treated psoriatic skin. [2]
  • Its an adipokine involved in lipolysis and adipozyte differentiation [3]

Classification

Hormone function

  • development and growth
    • environment adaptation
    • metabolism
      • nutrient supply

      Chemical classification

      Composition

      retinoic acid receptor responder protein 2

      Sequence
      VGVAELTEA QRRGLQVAL EEFHKHPPV 
      QWAFQETSV ESAVDTPFP AGIFVRLEF 
      KLQQTSCRK RDWKKPECK VRPNGRKRK 
      CLACIKLGS EDKVLGRLV HCPIETQVL 
      REAEEHQET QCLRVQRAG EDPHSFYFP 
      GQFAFSKAL PRS
      UniProt Q99969

      Links to other resources

      UniProt Q99969
      Ensembl ENST00000482669
      KEGG hsa:5919
      • Anatomical structure: liver

        • Abundant chemerin transcripts were found in liver, lung, pituitary, and ovary. [4]
        • Chemerin is secreted as a precursor of low biological activity, which upon proteolytic cleavage of its COOH-terminal domain, is converted into a potent and highly specific agonist of ChemR23, the chemerin receptor. [4]
      • Anatomical structure: lung

      • Anatomical structure: pituitary_gland_of_diencephalon

      • Anatomical structure: ovary

      Targets

      CellCMKLR1
      chondrocyte Present
      Influences
      • interleukin 6
      • IL-8
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • dendritic cell chemotaxis
      endothelial cell Present
      Phenotypes
      • angiogenesis
      macrophage Present
      Phenotypes
      • chemotaxis of macrophages
      Reference