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Details for messenger / hormone: SDF-1beta

EndoNet ID: ENH00689

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Synonyms

  • SDF-1b
  • intercrine reduced in hepatomas
  • Pre-B cell growth-stimulating factor
  • C-X-C motif chemokine 12
  • stromal cell-derived factor 1
  • SDF-1-beta(3-72)
  • stromal cell-derived factor 1 beta
  • CXCL12 protein beta
  • SDF-1beta
  • SDF1-beta
  • PBSF beta

General information

  • CXCR4 serves as a fusion cofactor for lymphotropic strains of human immunodeficiency virus type 1 and SDF1 inhibits viral entry. [1]
  • The chemokine stromal cell-derived factor-1 and its receptor, CXCR4, play a major role in migration, retention, and development of hematopoietic progenitors in the bone marrow. [2]
  • CXCL12 is locally produced by luteinizing granulosa cells. It specifically contributes to T lymphocytes recruitment and coordinates with local lymphocytes to increase granulosa cell survival and embryo quality. [3]
  • SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. [4]
  • SDF-1 is both necessary and sufficient to promote proliferative retinopathy. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    SDF-1-beta(3-72)

    Sequence
    VSLSYRCPC RFFESHVAR ANVKHLKIL 
    NTPNCALQI VARLKNNNR QVCIDPKLK 
    WIQEYLEKA LNKRFKM
    UniProt P48061-1

    Links to other resources

    UniProt P48061
    Ensembl ENST00000374429
    KEGG hsa:6387
    • Anatomical structure: substantia_propria_of_cornea

    • Anatomical structure: fibroblast

    Targets

    CellCXCR4
    hypothalamus Present
    Influences
    • antidiuretic hormone
    killer cell Present
    monocyte Present
    pituitary gland of diencephalon Present
    Influences
    • GH
    Reference