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Details for messenger / hormone: TNFSF15

EndoNet ID: ENH00691

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Synonyms

  • tumor necrosis factor ligand superfamily member 15
  • TNFSF15
  • VEGI
  • tumor necrosis factor (ligand) superfamily, member 15
  • vascular endothelial cell growth inhibitor
  • TNF ligand-related molecule 1
  • TL1A
  • VEGI-251

General information

  • The overexpression of full-length VEGI was completely without effect, but overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. [1]
  • VEGI is a member of the tumor necrosis factor super family and it is an endothelial cell-specific inhibitor of angiogenesis. [1]
  • This indicates that for VEGI action the secretion is essential. [1]

Classification

Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TNF family

      Composition

      VEGI-251 (membrane form)

      Sequence
      MAEDLGLSF GETASVEML PEHGSCRPK 
      ARSSSARWA LTCCLVLLP FLAGLTTYL 
      LVSQLRAQG EACVQFQAL KGQEFAPSH 
      QQVYAPLRA DGDKPRAHL TVVRQTPTQ 
      HFKNQFPAL HWEHELGLA FTKNRMNYT 
      NKFLLIPES GDYFIYSQV TFRGMTSEC 
      SEIRQAGRP NKPDSITVV ITKVTDSYP 
      EPTQLLMGT KSVCEVGSN WFQPIYLGA 
      MFSLQEGDK LMVNVSDIS LVDYTKEDK 
      TFFGAFLL

      VEGI-251 (secreted form)

      Sequence
      LKGQEFAPS HQQVYAPLR ADGDKPRAH 
      LTVVRQTPT QHFKNQFPA LHWEHELGL 
      AFTKNRMNY TNKFLLIPE SGDYFIYSQ 
      VTFRGMTSE CSEIRQAGR PNKPDSITV 
      VITKVTDSY PEPTQLLMG TKSVCEVGS 
      NWFQPIYLG AMFSLQEGD KLMVNVSDI 
      SLVDYTKED KTFFGAFLL

      Links to other resources

      UniProt O95150
      Ensembl ENST00000374045
      KEGG hsa:9966
      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      Targets

      CellDcR3TNFRSF25
      colon Present
      Phenotypes
      • positive regulation of lymphocyte apoptosis
      lymphocyte Present
      Phenotypes
      • positive regulation of lymphocyte apoptosis
      prostate Present
      Phenotypes
      • positive regulation of apoptosis
      spleen Present
      Phenotypes
      • positive regulation of lymphocyte apoptosis
      thymocyte Present
      Phenotypes
      • positive regulation of thymocyte apoptosis
      thymus Present
      Phenotypes
      • positive regulation of thymocyte apoptosis
      Reference