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Details for messenger / hormone: EG-VEGF

EndoNet ID: ENH00694

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Synonyms

  • Mambakine
  • endocrine-gland-derived vascular endothelial growth factor
  • Prokineticin-1
  • EG-VEGF
  • PROK1
  • prokineticin 1
  • endocrine gland-derived VEGF

General information

  • PROK1 stimulates cell proliferation, migration, and fenestrations in several endothelial cell lines derived from endocrine glands. [1]
  • Prokineticins are about 10 kD cysteine rich secreted proteins, which are expressed in the GI tract and several other tissues [1]
  • Prokineticin is a potentially important regulator of GI motility [1]
  • Selective angiogenic factor, has a cooperative role with VEGF in the regulation of angiogenesis in the human ovary. [2]
  • EG-VEGF is expressed only in steroidogenic glands and is mitogenic, motogenic and morphogenic for adrenal cortex endothelial cells. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • AVIT (prokineticin) family

      Composition

      Sequence
      MRGATRVSI MLLLVTVSD CAVITGACE 
      RDVQCGAGT CCAISLWLR GLRMCTPLG 
      REGEECHPG SHKVPFFRK RKHHTCPCL 
      PNLLCSRFP DGRYRCSMD LKNINF

      Links to other resources

      UniProt P58294
      Ensembl ENST00000271331
      KEGG hsa:84432
      • Anatomical structure: placenta

      • Anatomical structure: testis

      • Anatomical structure: ovary

      • Anatomical structure: digestive_system

      Targets

      CellProkineticin receptor 1
      cell of endometrium of uterus Present
      Influences
      • IL-11
      Reference