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Details for messenger / hormone: FLT3-Ligand

EndoNet ID: ENH00695

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Synonyms

  • SL cytokine
  • FLT3-Ligand
  • FLT3L
  • fms-related tyrosine kinase 3 Ligand
  • FL

General information

  • FLT3-Ligand is a cytokine, that plays an important role in the proliferation, survival and differentation of early murine and human hematopoietic precursor/stem cells. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence
    MTVLAPAWS PTTYLLLLL LLSSGLSGT 
    QDCSFQHSP ISSDFAVKI RELSDYLLQ 
    DYPVTVASN LQDEELCGA LWRLVLAQR 
    WMERLKTVA GSKMQGLLE RVNTEIHFV 
    TKCAFQPPP SCLRFVQTN ISRLLQETS 
    EQLVALKPW ITRQNFSRC LELQCQPDS 
    STLPPPWSP RPLEATAPT APQPPLLLL 
    LLLPVGLLL LAAAWCLHW QRTRRRTPR 
    PGEQVPPVP SPQDLLLVE H

    Links to other resources

    UniProt P49771
    Ensembl ENST00000204637
    KEGG hsa:2323

      Targets

      CellFLT3
      hematopoietic stem cell Present
      Phenotypes
      • hematopoiesis
      • Acute myeloid leukemia
      Reference