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Details for messenger / hormone: GDF-9

EndoNet ID: ENH00696

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Synonyms

  • growth/differentiation factor 9
  • GDF-9
  • Growth/Differentiation Factor-9

General information

  • It is important for the initial development of ovarian follicles. [1]
  • GDF-9 is a memmber of the TGFbeta super family and is produced by the oocyte. It is a cysteine knot-containing hormone. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence
      MARPNKFLL WFCCFAWLC FPISLGSQA 
      SGGEAQIAA SAELESGAM PWSLLQHID 
      ERDRAGLLP ALFKVLSVG RGGSPRLQP 
      DSRALHYMK KLYKTYATK EGIPKSNRS 
      HLYNTVRLF TPCTRHKQA PGDQVTGIL 
      PSVELLFNL DRITTVEHL LKSVLLYNI 
      NNSVSFSSA VKCVCNLMI KEPKSSSRT 
      LGRAPYSFT FNSQFEFGK KHKWIQIDV 
      TSLLQPLVA SNKRSIHMS INFTCMKDQ 
      LEHPSAQNG LFNMTLVSP SLILYLNDT 
      SAQAYHSWY SLHYKRRPS QGPDQERSL 
      SAYPVGEEA AEDGRSSHH RHRRGQETV 
      SSELKKPLG PASFNLSEY FRQFLLPQN 
      ECELHDFRL SFSQLKWDN WIVAPHRYN 
      PRYCKGDCP RAVGHRYGS PVHTMVQNI 
      IYEKLDSSV PRPSCVPAK YSPLSVLTI 
      EPDGSIAYK EYEDMIATK CTCR

      Links to other resources

      UniProt O60383
      Ensembl ENST00000378673
      KEGG hsa:2661
      • Anatomical structure: ovarian_follicle_cell

        • Growth differentiation factor-9 (GDF-9) is a glycoprotein secreted by the oocyte. [3]

      Targets

      CellBMP receptor type II
      adrenal cortex Present
      Phenotypes
      • negative regulation of steroid hormone biosynthetic
      • regulation of steroid biosynthetic process
      • negative regulation of adrenocorticotropin receptor activity
      Influences
      • aldosterone
      • aldosterone
      • cortisol
      adrenal medulla Present
      Phenotypes
      • regulation of cell fate specification
      • negative regulation of catecholamine biosynthetic process
      fibroblast Present
      heart Present
      hepatocyte Present
      skin Present
      Reference