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Details for messenger / hormone: IL-19

EndoNet ID: ENH00701

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Synonyms

  • NG.1
  • melanoma differentiation-associated protein-like protein
  • NG. 1
  • IL-19
  • Interleukin-19
  • melanoma differentiation associated protein-like protein
  • IL10C

General information

  • IL-19 plays an important role in the pathogenesis of asthma. [1]
  • IL-19 has a similarity of the amino acid identity of 21% in camparison to the IL-10. [2]
  • Due to their structural similarity, IL-19, IL-20, IL-22, IL-24 and IL-26 were combined with IL-10 in the so-called IL-10 family. [3]
  • IL-19 plays some important roles in inflammatory responses because it up-regulates IL-6 and induces apoptosis. [4]
  • The interaction between IL-19 and the proinflammatory cytokines contributes to systemic inflammatory responses after cardiopulmonary bypass. [5]
  • IL-19 plays a role in the complex pathological cytokine network in psoriasis. [6]
  • It is known, that IL-19 does not bind or signal through the normal IL-10 receptor complex. But it is unknown through which one it signals. [2]

Classification

Hormone function

  • development and growth
    • apoptosis
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • IL-10 family

        Composition

        Sequence 
        LRRCLISTD MHHIEESFQ EIKRAIQAK 
DTFPNVTIL STLETLQII KPLDVCCVT 
KNLLAFYVD RVFKDHQEP NPKILRKIS 
SIANSFLYM QKTLRQCQE QRQCHCRQE 
ATNATRVIH DNYDQLEVH AAAIKSLGE 
LDVFLAWIN KNHEVMSSA

        Links to other resources

        UniProt Q9UHD0
        Ensembl ENST00000422924
        KEGG hsa:29949

        • Anatomical structure: monocyte

          • The transscription of the IL-19 mRNA in the monocytes, can be induced by LPS-treatment [2]

        Targets

        CellIL-20R1IL-20R2
        No records found.
        Reference