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Details for messenger / hormone: IL-32

EndoNet ID: ENH00707

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Synonyms

  • tumor necrosis factor alpha-inducing factor
  • natural killer cells protein 4
  • Interleukin-32
  • IL-32
  • interleukin 32
  • NK4
  • natural killer cell transcript 4
  • IL32

General information

  • There are hints that IL-32 have an important role in the antibacterial defense and in inflammation [1]
  • Limited cleavage of IL-32alpha by PR3 enhances activities of the cytokine. [2]
  • It is recently known that IL-32 synergigizes with NOD1 and NOD2 ligand and so stimulate IL-1beta and IL-6 release in a caspase-1-dependent manner. [1]
  • Interleukin 32 plays an importat role in innate and adaptive immune responses. [1]
  • IL-32, a proinflammatory cytokine with four isoforms, induces IL-1beta, TNF-alpha, IL-6, and chemokines. [2]
  • It is even known that IFN-gamma stimulates the expression of IL-32. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Links to other resources

    UniProt P24001
    Ensembl ENST00000416912
    KEGG hsa:9235

    • Anatomical structure: epithelial_cell

    • Anatomical structure: T-lymphocyte

    Targets

    Cell
    No records found.
    Reference