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Details for messenger / hormone: BD-2

EndoNet ID: ENH00709

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Synonyms

  • defensin, beta 2
  • BD-2
  • hBD-2
  • beta-defensin 2
  • skin-antimicrobial peptide 1
  • SAP1

General information

  • An increase in intracellular calcium is essential for bacterially induced HBD-2 expression. [1]
  • Induced by mycobacteria.

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • antimicrobial peptides
          • beta-defensin family

      Composition

      Sequence 
      GIGDPVTCL KSGAICHPV FCPRRYKQI 
GTCGLPGTK CCKKP

      Links to other resources

      UniProt O15263
      Ensembl ENST00000302247
      KEGG hsa:1673

      • Anatomical structure: keratinocyte

      • Anatomical structure: epithelial_cell

        • Infection of human epithelial cells with mycobacteria induces HBD-2 mRNA expression in vitro. [1]

      Targets

      CellCCR6
      B-lymphocyte Present
      Phenotypes
      • chemotaxis of lymphocytes
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • dendritic cell chemotaxis
      memory cell T Present
      Phenotypes
      • chemotaxis of lymphocytes
      neutrophil granulocyte Present
      Phenotypes
      • Neutrophil chemotaxis
      Reference