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Details for messenger / hormone: BD-1

EndoNet ID: ENH00713

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Synonyms

  • defensin, beta 1
  • BD-1
  • beta-defensin 1
  • defensin beta 1
  • hBD-1

General information

  • HBD-1 is expressed by epithelial cells in many human organs. In some tissues, exemplified by the kidney, pancreas, and female reproductive tract, hBD-1 mRNA is sufficiently abundant to allow its facile identification by Northern blots. . [1]
  • The beta-defensin 1 gene is involved in the incidence and development of Atopic dermatitis, that is a chronic multifactorial allergic disease with unclear etiology. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • antimicrobial peptides
          • beta-defensin family

      Composition

      Sequence 
      DHYNCVSSG GQCLYSACP IFTKIQGTC 
YRGKAKCCK

      Links to other resources

      UniProt P60022
      Ensembl ENST00000297439
      KEGG hsa:1672

      • Anatomical structure: epithelial_cell

      • Anatomical structure: epithelial_cell_with_microvilli

      • Anatomical structure: kidney

      • Anatomical structure: pancreas

        • Pancreas and kidney expressed high levels of hBD-1. [1]

      • Anatomical structure: major_salivary_glands

        • Lower levels of hBD-1 were found in many organs by RT-PCR (salivary gland > trachea > prostate and placenta > thymus, testis, small intestine). [1]

      • Anatomical structure: trachea

      • Anatomical structure: placenta

      • Anatomical structure: prostate

      • Anatomical structure: testis

      • Anatomical structure: thymus

      • Anatomical structure: small_intestine

      Targets

      CellCCR6
      B-lymphocyte Present
      Phenotypes
      • chemotaxis of lymphocytes
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • dendritic cell chemotaxis
      memory cell T Present
      Phenotypes
      • chemotaxis of lymphocytes
      neutrophil granulocyte Present
      Phenotypes
      • Neutrophil chemotaxis
      Reference