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Details for messenger / hormone: BD-3

EndoNet ID: ENH00714

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Synonyms

  • defensin, beta 103
  • beta-defensin 103
  • BD-3
  • DEFB-3
  • hBD-3
  • HBD3
  • defensin-like protein
  • beta-defensin 103A
  • beta-defensin 3

General information

  • Exhibits antimicrobial activity against gram-positive bacteria S.aureus and S.pyogenes, gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistent E.faecium. [1]
  • Induction by infection of bacteria and by interferon gamma.

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • antimicrobial peptides
          • beta-defensin family

      Composition

      Sequence 
      GIINTLQKY YCRVRGGRC AVLSCLPKE 
EQIGKCSTR GRKCCRRKK

      Links to other resources

      UniProt P81534
      Ensembl ENST00000318124
      KEGG hsa:55894

        Targets

        CellTLR1TLR2
        alveolar macrophage Present
        Influences
        • TNF-alpha
        B-lymphocyte Present
        bone marrow Present
        bronchial epithelial cell Present
        		Present
        cervical canal of uterus Present
        		Present
        cholangiocyte Present
        		Present
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        		Present
        epithelial cell with microvilli Present
        		Present
        leukocyte Present
        		Present
        lipocyte of liver Present
        Phenotypes
        • regulation of innate immune response
        lymph node Present
        macrophage Present
        Influences
        • ↑ IL-1 beta
        		Present
        Influences
        • ↑ IL-1 beta
        monocyte Present
        Phenotypes
        • monocyte activation
        		Present
        Phenotypes
        • monocyte activation
        neutrophil granulocyte Present
        peripheral blood mononuclear cell (PBMC) Present
        Influences
        • ↑ TNF-alpha
        spleen Present
        T-lymphocyte Present
        vaginal mucosa Present
        		Present
        Reference