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Details for messenger / hormone: PGE1

EndoNet ID: ENH00728

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Synonyms

  • PGE1
  • prostaglandin E1
  • 9-oxo-11R,15S-dihydroxy-13E-prostaenoic acid
  • 7-[3(R)-Hydroxy-2(R)-(3(S)-hydroxy-1(E)-octenyl)-5-oxocyclopentan-1(R)-yl]-heptanoic acid
  • (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid

General information

  • PGE1 is used for the treatment of patients with peripheral artery disease. [1]
  • PGE1 improves the microcirculation and leads to the development of collateral circuits. [2]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • prostanoids
            • prostaglandins

      Composition

      Links to other resources

      LIPID MAPS LMFA03010134
      LipidBank XPR1400

        Targets

        CellEP1EP2EP3EP4PGI receptor
        beta cell of islet of Langerhans Present
        Influences
        • ↓ insulin
        brain Present
        cell of endometrium of uterus Present
        		Present
        		Present
        circulatory system hematopoietic system Present
        kidney Present
        		Present
        		Present
        large intestine Present
        lung Present
        Phenotypes
        • Pulmonary venous smooth muscle contraction
        		Present
        		Present
        		Present
        monocyte Present
        Influences
        • ↓ TNF-alpha
        		Present
        		Present
        Influences
        • ↓ IL-12
        • ↓ TNF-alpha
        		Present
        oesophagus Present
        Phenotypes
        • visceral pain hypersensitivity
        osteoblast Present
        Influences
        • ↑ interleukin 6
        • ↑ amphiregulin
        		Present
        Influences
        • ↑ interleukin 6
        • ↑ amphiregulin
        osteoclast Present
        		Present
        pancreas Present
        placenta Present
        		Present
        		Present
        platelet Present
        skeleton muscle Present
        small intestine Present
        		Present
        spleen Present
        thymus Present
        uterus Present
        		Present
        Reference