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Details for messenger / hormone: cripto-1

EndoNet ID: ENH00737

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Synonyms

  • cripto-1
  • CR-1
  • TDGF-1
  • teratocarcinoma-derived growth factor 1
  • CRIPTO
  • CR1
  • epidermal growth factor-like cripto protein CR1
  • cripto-1 growth factor
  • CRGF
  • TDGF1

General information

  • Cripto-1 is a target gene in a canonical Wnt3/beta-catenin/Lef-1 (Tcf) siganling pathway and also a coreceptor for Wnt and glypican-1. [1]
  • May have a role in tumorigenesis and in stem cell maintenance. [1]
  • CR-1 has a strong angiogenic activity, and regulates cellular migration and invasion. [1]
  • CR-1 can modulate milk protein expression, soluble CR-1 protein is secreted in human milk. [1]
  • GCNF binds to the CRIPTO-1 promoter and represses its transcription. [2]
  • Member of the EGF-CFC protein family, containing an NH2-terminal signal peptide, a modified EGF-like region, a conserved cysteine-rich domain (CFC motif) and a short hydrophobic COOH-terminus that contains additional sequences for glycosylphosphatidylinositol (GPI) cleavage and attachment. [1]
  • Cripto-1 can function both as a coreceptor in cis (autocrine/cell-autonomous) and as ligand in trans (paracrine/cell-nonautonomous). [1]
  • The major signaling pathways activated by cripto-1 are a Nodal/ALK4/ALK7/Smad-2 signaling pathway and a Glypican-1/c-Src/MAPK/AKT signaling pathway. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    cripto-1

    Sequence
    LGHQEFARP SRGYLAFRD DSIWPQEEP 
    AIRPRSSQR VPPMGIQHS KELNRTCCL 
    NGGTCMLGS FCACPPSFY GRNCEHDVR 
    KENCGSVPH DTWLPKKCS LCKCWHGQL 
    RCFPQAFLP GCDGLVMDE HLVASRTPE 
    LPPSARTTT FMLVGICLS IQSYY
    UniProt P13385

    Links to other resources

    UniProt P13385
    Ensembl ENST00000296145
    KEGG hsa:6997

      Targets

      Cellglypican 1
      bone marrow Present
      brain Present
      breast Present
      mammary gland Present
      ovary Present
      propria mucosa of bronchus Present
      skeleton muscle Present
      Reference