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Details for messenger / hormone: galectin-8

EndoNet ID: ENH00748

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Synonyms

  • Gal-8
  • galectin-8
  • LGALS8
  • lectin galactoside-binding soluble 8
  • PCTA-1
  • Po66-CBP
  • PCTA1
  • prostate carcinoma tumor antigen 1
  • Po66 carbohydrate-binding protein
  • GAL8
  • galectin 8

General information

  • Gal-8 constitutes a novel extracellular stimulus for T cells, able to bind specific beta1 integrins and to trigger signaling pathways conducive to cell spreading. [1]
  • Upon secretion galectin-8 acts as a physiological modulator of cell adhesion. When present in excess as a soluble ligand, galectin-8 (like fibronectin) forms a complex with integrins that negatively regulates cell adhesion. [2]
  • Galectin-8 modulates neutrophil function via interaction with integrin alphaM. [3]
  • Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. [4]
  • Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. [5]
  • Galectin-8 and galectin-9, which each consist of two carbohydrate recognition domains (CRDs) joined by a linker peptide, belong to the tandem-repeat-type subclass of the galectin family. [6]
  • The isoform with the longest linker peptide, that is, galectin-8L (G8L), is highly susceptible to thrombin cleavage, whereas the predominant isoform, galectin-8M (G8M), was resistant to thrombin. [6]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Links to other resources

    UniProt O00214
    Ensembl ENST00000366584
    KEGG hsa:3964

      Targets

      Cellintegrin alpha-1/beta-1integrin alpha-3/beta-1integrin alpha-5/beta-1
      beta cell of islet of Langerhans Present
      Influences
      • insulin
      epithelial cell Present
      keratinocyte Present
      smooth muscle cell Present
      Phenotypes
      • smooth muscle cell migration
      Reference