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Details for messenger / hormone: angiogenin

EndoNet ID: ENH00756

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Synonyms

  • angiogenin ribonuclease RNase A family 5
  • angiogenin
  • ribonuclease 5
  • RNase 5
  • RNASE5

General information

  • Angiogenin is a normal constituent of the circulation and contained in a vasculature that rarely undergoes proliferation, but in some physiological and pathological conditions its levels increase in blood, promoting neovascularization. [1]
  • Up-regulated by hypoxia.
  • Angiogenin is a polypeptide involved in the formation and establishment of new blood vessels necessary for growth and metastasis of numerous malignant neoplasms, including prostatic adenocarcinoma. [2]
  • May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. [3]
  • Angiogenin is a member of the ribonuclease (RNase) superfamily: enzymes of innate substrate specificity, but divergent functional capacities. [1]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • cancer / metastasis

      Chemical classification

      Composition

      Angiogenin.

      Sequence 
      QDNSRYTHF LTQHYDAKP QGRDDRYCE 
SIMRRRGLT SPCKDINTF IHGNKRSIK 
AICENKNGN PHRENLRIS KSSFQVTTC 
KLHGGSPWP PCQYRATAG FRNVVVACE 
NGLPVHLDQ SIFRRP
      UniProt P03950

      Links to other resources

      UniProt P03950
      Ensembl ENST00000397990
      KEGG hsa:283

      • Anatomical structure: neuron

        • Our studies indicate that angiogenin is a neuronally derived protein which constitutively and inducibly modifies the RNA profile of astroglia in paracrine. [4]

      Targets

      CellSyndecan-4
      astrocyte Present
      Reference