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Details for messenger / hormone: VEGF-189

EndoNet ID: ENH00759

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Synonyms

  • vascular permeability factor
  • vascular endothelial growth factor A
  • VEGF-189
  • VEGF189
  • VEGF(189)
  • V(189)

General information

  • Highly basic polypeptide binding to heparin with high affinity. Almost completely sequestred in the extracellular matrix. [1]
  • VEGF189 stimulates endothelial cells proliferation and migration and up-regulates the expression of Flk-1/KDR mRNA. [2]
  • Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma. [3]
  • VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence 
      APMAEGGGQ NHHEVVKFM DVYQRSYCH 
PIETLVDIF QEYPDEIEY IFKPSCVPL 
MRCGGCCND EGLECVPTE ESNITMQIM 
RIKPHQGQH IGEMSFLQH NKCECRPKK 
DRARQEKKS VRGKGKGQK RKRKKSRYK 
SWSVPCGPC SERRKHLFV QDPQTCKCS 
CKNTDSRCK ARQLELNER TCRCDKPRR

      Links to other resources

      UniProt P15692-2
      Ensembl ENST00000372055
      KEGG hsa:7422

      • Anatomical structure: hepatocyte

      Targets

      Cell
      No records found.
      Reference