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Details for messenger / hormone: soluble VEGFR-1

EndoNet ID: ENH00764

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  • soluble VEGFR1
  • soluble VEGFR-1
  • sVEGFR1
  • sVEGFR-1
  • sFlt-1
  • soluble Flt-1

General information

  • Secretion of sVEGFR-1 is increased by the angiogenic factor bFGF in human ECs and is also enhanced in lipopolysaccharide-activated human monocytes. [1]
  • sFlt-1 suppresses growth and peritoneal dissemination of ovarian cancer by the inhibition of angiogenesis. [2]
  • Soluble VEGF receptor, potentially useful as an antagonist of VEGF.


Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    Links to other resources

    • Anatomical structure: monocyte

    • Anatomical structure: serum

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Microvascular and macrovascular endothelial cells.
    • Anatomical structure: amniotic_fluid

    • Anatomical structure: placenta


    No records found.