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Details for messenger / hormone: endostatin

EndoNet ID: ENH00767

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Synonyms

  • collagen alpha-1(XVIII) chain
  • endostatin

General information

  • Endostatin binding to alpha-5/beta-1 integrin leads to the inhibition of focal adhesion kinase/c-Raf/MEK1/2/p38/ERK1 mitogen-activated protein kinase pathway, with no effect on phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 and Cap-dependent translation. [1]
  • Product of the COL18A1-gene.
  • Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. [2]
  • Tumstatin prevents angiogenesis via inhibition of endothelial cell proliferation and promotion of apoptosis with no effect on migration, whereas human endostatin prevents endothelial cell migration with no effect on proliferation. [1]
  • Endostatin is the C-terminal antiangiogenic fragment of the extracellular matrix protein collagen XVIII, and is generated by tumor-derived proteases. [3]
  • Endostatin can specifically inhibit endothelial proliferation and potently inhibit angiogenesis and tumor growth. [4]
  • Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation. [5]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • growth stimulation

      Chemical classification

      Links to other resources

      UniProt P39060
      Ensembl ENST00000359759
      KEGG hsa:80781

        Targets

        Reference