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Details for messenger / hormone: secretoneurin

EndoNet ID: ENH00774

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Synonyms

  • Chromogranin-C
  • secretogranin II
  • Secretogranin-2
  • SN
  • secretoneurin

General information

  • SN might play a role in recruitment of monocytes to inflamed tissue. [1]
  • Secretoneurin increases monolayer permeability in human coronary artery endothelial cells. [2]
  • Secretoneurin stimulates directed migration of natural killer cells and may modulate Th1/Th2-response via affecting chemokine release. [3]
  • The angiogenic neuropeptide secretoneurin stimulates postnatal vasculogenesis by mobilization, migration, and incorporation of endothelial progenitor cells. [4]
  • Secretoneurin represents a direct angiogenic cytokine and reiterate the coordinated relationship between nervous and vascular systems. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • chromogranin/secretogranin family

        Composition

        secretoneurin, peptide

        Sequence
        TNEIVEEQY TPQSLATLE SVFQELGKL 
        TGPNNQ

        Links to other resources

        UniProt P13521
        Ensembl ENST00000305409
        KEGG hsa:7857
        • Anatomical structure: basophil_gonadotroph_cell_of_anterior_pituitary_FSH

          Influenced by:

          • gonadotropin-releasing hormone receptor
            in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
            • Co-localization and co-release of LH and SgII in vivo. [6]
            • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [7]
        • Anatomical structure: hypothalamus

          • The highest concentrations of this peptide were present in the hypothalamus, in particular, in the median eminence and are comparable to those of the most highly concentrated neuropeptides. [8]

        Targets

        Cell
        No records found.
        Reference