Status
Please wait ...

Details for messenger / hormone: soluble mesothelin

EndoNet ID: ENH00802

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • soluble mesothelin
  • SMR
  • mesothelin, cleaved form
  • MSLN
  • MPF
  • soluble mesothelin-related protein
  • SMRP

General information

  • A soluble 42–45-kDa protein with an NH2-terminal amino acid sequence, identical to that of the membrane-bound portion of mesothelin. [1]
  • The small amount of mesothelin shed into the serum could make it a valuable diagnostic tool in cancers that express mesothelin. [1]
  • Mesothelin is up-regulated by Wnt-1. [1]

Classification

Hormone function

  • development and growth
    • cancer / metastasis

    Chemical classification

    Links to other resources

    • Anatomical structure: mesothelial_cell

      • Mesothelin and its soluble isoforms (SMRP) are synthesized by mesothelial cells but only in a state of serious pathology such as carcinogenesis. [2]

    Targets

    Cell
    No records found.
    Reference