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Details for messenger / hormone: prostasin

EndoNet ID: ENH00804

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  • PRSS8
  • serine protease 8
  • prostasin light chain
  • prostasin heavy chain
  • prostasin

General information

  • Prostasin has been shown to regulate sodium handling in the kidney. [1]
  • Prostasin, a trypsinlike serine peptidase, is highly expressed in prostate, kidney, and lung epithelia, where it is bound to the cell surface, secreted, or both. [2]
  • Prostasin activates the epithelial sodium channel (ENaC) and suppresses invasion of prostate and breast cancer cells. [2]
  • Serine protease that plays a role in regulation of the amiloride-sensitive epithelial sodium channel, and is overexpressed in ovarian cancer cells. [3]


Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    Links to other resources

    UniProt Q16651
    Ensembl ENST00000317508
    KEGG hsa:5652
    • Anatomical structure: kidney

      • We report that endogenous mouse prostasin is glycosylphosphatidylinositol (GPI) anchored to the cell surface and is constitutively secreted from the apical surface of kidney cortical collecting duct cells. [2]
      • We show that prostasin secretion depends on GPI anchor cleavage by endogenous GPI-specific phospholipase D1 (Gpld1). [2]


    No records found.