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Details for messenger / hormone: MIF

EndoNet ID: ENH00809

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Synonyms

  • L-dopachrome isomerase
  • L-dopachrome tautomerase
  • MIF
  • macrophage migration inhibitory factor
  • GLIF
  • MMIF
  • glycosylation-inhibiting factor
  • phenylpyruvate tautomerase
  • GIF
  • macrophage migration inhibitory factor 1alpha
  • MIF 1alpha

General information

  • MIF binds to the extracellular domain of CD74, and CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production. [1]
  • MIF is a proinflammatory type 1 cytokine that plays a pathogenic role in several inflammatory and autoimmune diseases. It seems to be also crucially involved in Guillain-Barre syndrome and experimental allergic neuritis. [2]
  • Tumor-derived macrophage migration inhibitory factor (MIF) inhibits T lymphocyte activation. [3]
  • MIF promotes malignant cell transformation, inhibits tumour cell-specific immune cytolytic responses and strongly enhances neovascularization. [4]
  • MIF functions as a pluripotent cytokine involved in broad-spectrum pathophysiological events in association with inflammation and immune responses. MIF is probably also involved in tumorigenesis. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    Macrophage migration inhibitory factor.

    Sequence
    PMFIVNTNV PRASVPDGF LSELTQQLA 
    QATGKPPQY IAVHVVPDQ LMAFGGSSE 
    PCALCSLHS IGKIGGAQN RSYSKLLCG 
    LLAERLRIS PDRVYINYY DMNAANVGW 
    NNSTFA
    UniProt P14174

    Links to other resources

    UniProt P14174
    Ensembl ENST00000215754
    KEGG hsa:4282
    • Anatomical structure: fat_cell

    • Anatomical structure: adipose_tissue

    Targets

    CellCD74
    No records found.
    Reference