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Details for messenger / hormone: CBG

EndoNet ID: ENH00820

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Synonyms

  • CBG
  • transcortin
  • serpin A6
  • corticosteroid-binding globulin
  • serine proteinase inhibitor clade A member 6
  • cortisol-binding globulin

General information

  • CBG binds corticosteroids in plasma, delivering them to sites of inflammation to modify the inflammatory response. [1]
  • Corticosteroid-binding globulin is a plasma glycoprotein that is primarily synthesized in the liver and binds cortisol and progesterone with high affinity. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • serpin family

      Links to other resources

      UniProt P08185
      Ensembl ENST00000341584
      KEGG hsa:866

      • Anatomical structure: hepatocyte

        • CBG is secreted from hepatocytes as a 383-amino-acid peptide after cleavage of a 22-amino-acid signal peptide and circulates at concentrations ranging from 30 to 52 pg/ml. [3]

        Influenced by:

        • glucocorticoid receptor
          in hepatocyte
          • Levels of CBG are decreased by glucocorticoids. The effects of glucocorticoids on CBG synthesis are glucocorticoid receptor dependent. [3]
        • ER-alpha
          in liver
          • Our results show that o,p′-DDD (mitotane) increases CBG expression and secretion by an ERα-dependent mechanism. [4]

      Targets

      Cell
      No records found.
      Reference