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Details for messenger / hormone: chordin-like protein 2

EndoNet ID: ENH00821

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Synonyms

  • BNF-1
  • chordin-related protein 2
  • breast tumor novel factor 1
  • chordin-like 2
  • chordin-like protein 2
  • CHRDL2
  • BNF1
  • CHL2

General information

  • Overexpressed in tumor tissues. [1]
  • Directly interacts with different BMPs, inhibiting their actions in a manner similar to chordin, noggin and CHL1. [2]
  • hCHL2, a chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. [3]
  • Possible role during formation and maintenance of articular cartilage and reproductive organs. [2]
  • CHL2 might negatively regulate cartilage formation/regeneration in diseased joints. [2]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      Composition

      Chordin-like protein 2.

      Sequence 
      RARPDMFCL FHGKRYSPG ESWHPYLEP 
QGLMYCLRC TCSEGAHVS CYRLHCPPV 
HCPQPVTEP QQCCPKCVE PHTPSGLRA 
PPKSCQHNG TMYQHGEIF SAHELFPSR 
LPNQCVLCS CTEGQIYCG LTTCPEPGC 
PAPLPLPDS CCQACKDEA SEQSDEEDS 
VQSLHGVRH PQDPCSSDA GRKRGPGTP 
APTGLSAPL SFIPRHFRP KGAGSTTVK 
IVLKEKHKK ACVHGGKTY SHGEVWHPA 
FRAFGPLPC ILCTCEDGR QDCQRVTCP 
TEYPCRHPE KVAGKCCKI CPEDKADPG 
HSEISSTRC PKAPGRVLV HTSVSPSPD 
NLRRFALEH EASDLVEIY LWKLVKGIF 
HLTQIKKVR KQDFQKEAQ HFRLLAGPH 
EGHWNVFLA QTLELKVTA SPDKVTKT
      UniProt Q6WN34

      Links to other resources

      UniProt Q6WN34
      Ensembl ENST00000376332
      KEGG hsa:25884

      • Anatomical structure: chondrocyte

      • Anatomical structure: osteoblast

      • Anatomical structure: cartilage

      Targets

      Cell
      No records found.
      Reference