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Details for messenger / hormone: laminin-11

EndoNet ID: ENH00824

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Synonyms

  • laminin-11
  • laminin 11
  • laminin alpha-5/beta-2/gamma-1
  • laminin alpha5/beta2/gamma1
  • laminin alpha5beta2gamma1

General information

  • Laminin is essential for basement membrane assembly, promotes cell attachment and angiogenesis, induces neurite outgrowth, affects gene expression and is involved in cell proliferation, migration and differentiation. [1]
  • MAPK are involved in laminin signaling. [1]
  • Laminin promotes tumor cell invasion by induction of proteases that degrade various components of the extracellular matrix. [1]
  • Elongated alpha5-chain short arm, larger than original full-sized laminins. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • metabolism
      • cell metabolism

      Chemical classification

      Composition

      subunit alpha-5

      Sequence
      REEAGGGFS LHPPYFNLA EGARIAASA 
      TCGEEAPAR GSPRPTEDL YCKLVGGPV 
      AGGDPNQTI RGQYCDICT AANSNKAHP 
      ASNAIDGTE RWWQSPPLS RGLEYNEVN 
      VTLDLGQVF HVAYVLIKF ANSPRPDLW 
      VLERSMDFG RTYQPWQFF ASSKRDCLE 
      RFGPQTLER ITRDDAAIC TTEYSRIVP 
      LENGEIVVS LVNGRPGAM NFSYSPLLR 
      EFTKATNVR LRFLRTNTL LGHLMGKAL 
      RDPTVTRRY YYSIKDISI GGRCVCHGH 
      ADACDAKDP TDPFRLQCT CQHNTCGGT 
      CDRCCPGFN QQPWKPATA NSANECQSC 
      NCYGHATDC YYDPEVDRR RASQSLDGT 
      YQGGGVCID CQHHTTGVN CERCLPGFY 
      RSPNHPLDS PHVCRRCNC ESDFTDGTC 
      EDLTGRCYC RPNFSGERC DVCAEGFTG 
      FPSCYPTPS SSNDTREQV LPAGQIVNC 
      DCSAAGTQG NACRKDPRV GRCLCKPNF 
      QGTHCELCA PGFYGPGCQ PCQCSSPGV 
      ADDRCDPDT GQCRCRVGF EGATCDRCA 
      PGYFHFPLC QLCGCSPAG TLPEGCDEA 
      GRCLCQPEF AGPHCDRCR PGYHGFPNC 
      QACTCDPRG ALDQLCGAG GLCRCRPGY 
      TGTACQECS PGFHGFPSC VPCHCSAEG 
      SLHAACDPR SGQCSCRPR VTGLRCDTC 
      VPGAYNFPY CEAGSCHPA GLAPVDPAL 
      PEAQVPCMC RAHVEGPSC DRCKPGFWG 
      LSPSNPEGC TRCSCDLRG TLGGVAECQ 
      PGTGQCFCK PHVCGQACA SCKDGFFGL 
      DQADYFGCR SCRCDIGGA LGQSCEPRT 
      GVCRCRPNT QGPTCSEPA RDHYLPDLH 
      HLRLELEEA ATPEGHAVR FGFNPLEFE 
      NFSWRGYAQ MAPVQPRIV ARLNLTSPD 
      LFWLVFRYV NRGAMSVSG RVSVREEGR 
      SATCANCTA QSQPVAFPP STEPAFITV 
      PQRGFGEPF VLNPGTWAL RVEAEGVLL 
      DYVVLLPSA YYEAALLQL RVTEACTYR 
      PSAQQSGDN CLLYTHLPL DGFPSAAGL 
      EALCRQDNS LPRPCPTEQ LSPSHPPLI 
      TCTGSDVDV QLQVAVPQP GRYALVVEY 
      ANEDARQEV GVAVHTPQR APQQGLLSL 
      HPCLYSTLC RGTARDTQD HLAVFHLDS 
      EASVRLTAE QARFFLHGV TLVPIEEFS 
      PEFVEPRVS CISSHGAFG PNSAACLPS 
      RFPKPPQPI ILRDCQVIP LPPGLPLTH 
      AQDLTPAMS PAGPRPRPP TAVDPDAEP 
      TLLREPQAT VVFTTHVPT LGRYAFLLH 
      GYQPAHPTF PVEVLINAG RVWQGHANA 
      SFCPHGYGC RTLVVCEGQ ALLDVTHSE 
      LTVTVRVPK GRWLWLDYV LVVPENVYS 
      FGYLREEPL DKSYDFISH CAAQGYHIS 
      PSSSSLFCR NAAASLSLF YNNGARPCG 
      CHEVGATGP TCEPFGGQC PCHAHVIGR 
      DCSRCATGY WGFPNCRPC DCGARLCDE 
      LTGQCICPP RTIPPDCLL CQPQTFGCH 
      PLVGCEECN CSGPGIQEL TDPTCDTDS 
      GQCKCRPNV TGRRCDTCS PGFHGYPRC 
      RPCDCHEAG TAPGVCDPL TGQCYCKEN 
      VQGPKCDQC SLGTFSLDA ANPKGCTRC 
      FCFGATERC RSSSYTRQE FVDMEGWVL 
      LSTDRQVVP HERQPGTEM LRADLRHVP 
      EAVPEAFPE LYWQAPPSY LGDRVSSYG 
      GTLRYELHS ETQRGDVFV PMESRPDVV 
      LQGNQMSIT FLEPAYPTP GHVHRGQLQ 
      LVEGNFRHT ETRNTVSRE ELMMVLASL 
      EQLQIRALF SQISSAVFL RRVALEVAS 
      PAGQGALAS NVELCLCPA SYRGDSCQE 
      CAPGFYRDV KGLFLGRCV PCQCHGHSD 
      RCLPGSGVC VDCQHNTEG AHCERCQAG 
      FVSSRDDPS APCVSCPCP LSVPSNNFA 
      EGCVLRGGR TQCLCKPGY AGASCERCA 
      PGFFGNPLV LGSSCQPCD CSGNGDPNL 
      LFSDCDPLT GACRGCLRH TTGPRCEIC 
      APGFYGNAL LPGNCTRCD CTPCGTEAC 
      DPHSGHCLC KAGVTGRRC DRCQEGHFG 
      FDGCGGCRP CACGPAAEG SECHPQSGQ 
      CHCRPGTMG PQCRECAPG YWGLPEQGC 
      RRCQCPGGR CDPHTGRCN CPPGLSGER 
      CDTCSQQHQ VPVPGGPVG HSIHCEVCD 
      HCVVLLLDD LERAGALLP AIHEQLRGI 
      NASSMAWAR LHRLNASIA DLQSQLRSP 
      LGPRHETAQ QLEVLEQQS TSLGQDARR 
      LGGQAVGTR DQASQLLAG TEATLGHAK 
      TLLAAIRAV DRTLSELMS QTGHLGLAN 
      ASAPSGEQL LRTLAEVER LLWEMRARD 
      LGAPQAAAE AELAAAQRL LARVQEQLS 
      SLWEENQAL ATQTRDRLA QHEAGLMDL 
      REALNRAVD ATREAQELN SRNQERLEE 
      ALQRKQELS RDNATLQAT LHAARDTLA 
      SVFRLLHSL DQAKEELER LAASLDGAR 
      TPLLQRMQT FSPAGSKLR LVEAAEAHA 
      QQLGQLALN LSSIILDVN QDRLTQRAI 
      EASNAYSRI LQAVQAAED AAGQALQQA 
      DHTWATVVR QGLVDRAQQ LLANSTALE 
      EAMLQEQQR LGLVWAALQ GARTQLRDV 
      RAKKDQLEA HIQAAQAML AMDTDETSK 
      KIAHAKAVA AEAQDTATR VQSQLQAMQ 
      ENVERWQGQ YEGLRGQDL GQAVLDAGH 
      SVSTLEKTL PQLLAKLSI LENRGVHNA 
      SLALSASIG RVRELIAQA RGAASKVKV 
      PMKFNGRSG VQLRTPRDL ADLAAYTAL 
      KFYLQGPEP EPGQGTEDR FVMYMGSRQ 
      ATGDYMGVS LRDKKVHWV YQLGEAGPA 
      VLSIDEDIG EQFAAVSLD RTLQFGHMS 
      VTVERQMIQ ETKGDTVAP GAEGLLNLR 
      PDDFVFYVG GYPSTFTPP PLLRFPGYR 
      GCIEMDTLN EEVVSLYNF ERTFQLDTA 
      VDRPCARSK STGDPWLTD GSYLDGTGF 
      ARISFDSQI STTKRFEQE LRLVSYSGV 
      LFFLKQQSQ FLCLAVQEG SLVLLYDFG 
      AGLKKAVPL QPPPPLTSA SKAIQVFLL 
      GGSRKRVLV RVERATVYS VEQDNDLEL 
      ADAYYLGGV PPDQLPPSL RRLFPTGGS 
      VRGCVKGIK ALGKYVDLK RLNTTGVSA 
      GCTADLLVG RAMTFHGHG FLRLALSNV 
      APLTGNVYS GFGFHSAQD SALLYYRAS 
      PDGLCQVSL QQGRVSLQL LRTEVKTQA 
      GFADGAPHY VAFYSNATG VWLYVDDQL 
      QQMKPHRGP PPELQPQPE GPPRLLLGG 
      LPESGTIYN FSGCISNVF VQRLLGPQR 
      VFDLQQNLG SVNVSTGCA PALQAQTPG 
      LGPRGLQAT ARKASRRSR QPARHPACM 
      LPPHLRTTR DSYQFGGSL SSHLEFVGI 
      LARHRNWPS LSMHVLPRS SRGLLLFTA 
      RLRPGSPSL ALFLSNGHF VAQMEGLGT 
      RLRAQSRQR SRPGRWHKV SVRWEKNRI 
      LLVTDGARA WSQEGPHRQ HQGAEHPQP 
      HTLFVGGLP ASSHSSKLP VTVGFSGCV 
      KRLRLHGRP LGAPTRMAG VTPCILGPL 
      EAGLFFPGS GGVITLDLP GATLPDVGL 
      ELEVRPLAV TGLIFHLGQ ARTPPYLQL 
      QVTEKQVLL RADDGAGEF STSVTRPSV 
      LCDGQWHRL AVMKSGNVL RLEVDAQSN 
      HTVGPLLAA AAGAPAPLY LGGLPEPMA 
      VQPWPPAYC GCMRRLAVN RSPVAMTRS 
      VEVHGAVGA SGCPAA
      UniProt O15230

      subunit beta-2

      Sequence
      QAPAPDVPG CSRGSCYPA TGDLLVGRA 
      DRLTASSTC GLNGPQPYC IVSHLQDEK 
      KCFLCDSRR PFSARDNPH SHRIQNVVT 
      SFAPQRRAA WWQSENGIP AVTIQLDLE 
      AEFHFTHLI MTFKTFRPA AMLVERSAD 
      FGRTWHVYR YFSYDCGAD FPGVPLAPP 
      RHWDDVVCE SRYSEIEPS TEGEVIYRV 
      LDPAIPIPD PYSSRIQNL LKITNLRVN 
      LTRLHTLGD NLLDPRREI REKYYYALY 
      ELVVRGNCF CYGHASECA PAPGAPAHA 
      EGMVHGACI CKHNTRGLN CEQCQDFYR 
      DLPWRPAED GHSHACRKC ECHGHTHSC 
      HFDMAVYLA SGNVSGGVC DGCQHNTAG 
      RHCELCRPF FYRDPTKDL RDPAVCRSC 
      DCDPMGSQD GGRCDSHDD PALGLVSGQ 
      CRCKEHVVG TRCQQCRDG FFGLSISDR 
      LGCRRCQCN ARGTVPGST PCDPNSGSC 
      YCKRLVTGR GCDRCLPGH WGLSHDLLG 
      CRPCDCDVG GALDPQCDE GTGQCHCRQ 
      HMVGRRCEQ VQPGYFRPF LDHLIWEAE 
      DTRGQVLDV VERLVTPGE TPSWTGSGF 
      VRLQEGQTL EFLVASVPK AMDYDLLLR 
      LEPQVPEQW AELELIVQR PGPVPAHSL 
      CGHLVPKDD RIQGTLQPH ARYLIFPNP 
      VCLEPGISY KLHLKLVRT GGSAQPETP 
      YSGPGLLID SLVLLPRVL VLEMFSGGD 
      AAALERQAT FERYQCHEE GLVPSKTSP 
      SEACAPLLI SLSTLIYNG ALPCQCNPQ 
      GSLSSECNP HGGQCLCKP GVVGRRCDL 
      CAPGYYGFG PTGCQACQC SHEGALSSL 
      CEKTSGQCL CRTGAFGLR CDRCQRGQW 
      GFPSCRPCV CNGHADECN THTGACLGC 
      RDHTGGEHC ERCIAGFHG DPRLPYGGQ 
      CRPCPCPEG PGSQRHFAT SCHQDEYSQ 
      QIVCHCRAG YTGLRCEAC APGHFGDPS 
      RPGGRCQLC ECSGNIDPM DPDACDPHT 
      GQCLRCLHH TEGPHCAHC KPGFHGQAA 
      RQSCHRCTC NLLGTNPQQ CPSPDQCHC 
      DPSSGQCPC LPNVQGPSC DRCAPNFWN 
      LTSGHGCQP CACHPSRAR GPTCNEFTG 
      QCHCRAGFG GRTCSECQE LHWGDPGLQ 
      CHACDCDSR GIDTPQCHR FTGHCSCRP 
      GVSGVRCDQ CARGFSGIF PACHPCHAC 
      FGDWDRVVQ DLAARTQRL EQRAQELQQ 
      TGVLGAFES SFWHMQEKL GIVQGIVGA 
      RNTSAASTA QLVEATEEL RREIGEATE 
      HLTQLEADL TDVQDENFN ANHALSGLE 
      RDRLALNLT LRQLDQHLD LLKHSNFLG 
      AYDSIRHAH SQSAEAERR ANTSALAVP 
      SPVSNSASA RHRTEALMD AQKEDFNSK 
      HMANQRALG KLSAHTHTL SLTDINELV 
      CGAPGDAPC ATSPCGGAG CRDEDGQPR 
      CGGLSCNGA AATADLALG RARHTQAEL 
      QRALAEGGS ILSRVAETR RQASEAQQR 
      AQAALDKAN ASRGQVEQA NQELQELIQ 
      SVKDFLNQE GADPDSIEM VATRVLELS 
      IPASAEQIQ HLAGAIAER VRSLADVDA 
      ILARTVGDV RRAEQLLQD ARRARSWAE 
      DEKQKAETV QAALEEAQR AQGIAQGAI 
      RGAVADTRD TEQTLYQVQ ERMAGAERA 
      LSSAGERAR QLDALLEAL KLKRAGNSL 
      AASTAEETA GSAQGRAQE AEQLLRGPL 
      GDQYQTVKA LAERKAQGV LAAQARAEQ 
      LRDEARDLL QAAQDKLQR LQELEGTYE 
      ENERALESK AAQLDGLEA RMRSVLQAI 
      NLQVQIYNT CQ
      UniProt P55268

      subunit gamma-1

      Sequence
      QAAMDECTD EGGRPQRCM PEFVNAAFN 
      VTVVATNTC GTPPEEYCV QTGVTGVTK 
      SCHLCDAGQ PHLQHGAAF LTDYNNQAD 
      TTWWQSQTM LAGVQYPSS INLTLHLGK 
      AFDITYVRL KFHTSRPES FAIYKRTRE 
      DGPWIPYQY YSGSCENTY SKANRGFIR 
      TGGDEQQAL CTDEFSDIS PLTGGNVAF 
      STLEGRPSA YNFDNSPVL QEWVTATDI 
      RVTLNRLNT FGDEVFNDP KVLKSYYYA 
      ISDFAVGGR CKCNGHASE CMKNEFDKL 
      VCNCKHNTY GVDCEKCLP FFNDRPWRR 
      ATAESASEC LPCDCNGRS QECYFDPEL 
      YRSTGHGGH CTNCQDNTD GAHCERCRE 
      NFFRLGNNE ACSSCHCSP VGSLSTQCD 
      SYGRCSCKP GVMGDKCDR CQPGFHSLT 
      EAGCRPCSC DPSGSIDEC NIETGRCVC 
      KDNVEGFNC ERCKPGFFN LESSNPRGC 
      TPCFCFGHS SVCTNAVGY SVYSISSTF 
      QIDEDGWRA EQRDGSEAS LEWSSERQD 
      IAVISDSYF PRYFIAPAK FLGKQVLSY 
      GQNLSFSFR VDRRDTRLS AEDLVLEGA 
      GLRVSVPLI AQGNSYPSE TTVKYVFRL 
      HEATDYPWR PALTPFEFQ KLLNNLTSI 
      KIRGTYSER SAGYLDDVT LASARPGPG 
      VPATWVESC TCPVGYGGQ FCEMCLSGY 
      RRETPNLGP YSPCVLCAC NGHSETCDP 
      ETGVCNCRD NTAGPHCEK CSDGYYGDS 
      TAGTSSDCQ PCPCPGGSS CAVVPKTKE 
      VVCTNCPTG TTGKRCELC DDGYFGDPL 
      GRNGPVRLC RLCQCSDNI DPNAVGNCN 
      RLTGECLKC IYNTAGFYC DRCKDGFFG 
      NPLAPNPAD KCKACNCNL YGTMKQQSS 
      CNPVTGQCE CLPHVTGQD CGACDPGFY 
      NLQSGQGCE RCDCHALGS TNGQCDIRT 
      GQCECQPGI TGQHCERCE VNHFGFGPE 
      GCKPCDCHP EGSLSLQCK DDGRCECRE 
      GFVGNRCDQ CEENYFYNR SWPGCQECP 
      ACYRLVKDK VADHRVKLQ ELESLIANL 
      GTGDEMVTD QAFEDRLKE AEREVMDLL 
      REAQDVKDV DQNLMDRLQ RVNNTLSSQ 
      ISRLQNIRN TIEETGNLA EQARAHVEN 
      TERLIEIAS RELEKAKVA AANVSVTQP 
      ESTGDPNNM TLLAEEARK LAERHKQEA 
      DDIVRVAKT ANDTSTEAY NLLLRTLAG 
      ENQTAFEIE ELNRKYEQA KNISQDLEK 
      QAARVHEEA KRAGDKAVE IYASVAQLS 
      PLDSETLEN EANNIKMEA ENLEQLIDQ 
      KLKDYEDLR EDMRGKELE VKNLLEKGK 
      TEQQTADQL LARADAAKA LAEEAAKKG 
      RDTLQEAND ILNNLKDFD RRVNDNKTA 
      AEEALRKIP AINQTITEA NEKTREAQQ 
      ALGSAAADA TEAKNKAHE AERIASAVQ 
      KNATSTKAE AERTFAEVT DLDNEVNNM 
      LKQLQEAEK ELKRKQDDA DQDMMMAGM 
      ASQAAQEAE INARKAKNS VTSLLSIIN 
      DLLEQLGQL DTVDLNKLN EIEGTLNKA 
      KDEMKVSDL DRKVSDLEN EAKKQEAAI 
      MDYNRDIEE IMKDIRNLE DIRKTLPSG 
      CFNTPSIEK P
      UniProt P11047

      Links to other resources

        Targets

        Cellintegrin alpha-3/beta-1integrin alpha-6/beta-1
        keratinocyte Present
        oligodendrocyte Present
        smooth muscle cell Present
        Phenotypes
        • smooth muscle cell migration
        Reference