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Details for messenger / hormone: laminin-4

EndoNet ID: ENH00827

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Synonyms

  • LN-4
  • laminin-4
  • laminin 4
  • laminin alpha-2/beta-2/gamma-1
  • laminin alpha2/beta2/gamma1
  • laminin alpha2-beta2-gamma1
  • laminin alpha2beta2gamma1

General information

  • Interaction with dystroglycan is heparin-independent. [1]
  • Binds to nidogen/entactin. [1]
  • Laminin is essential for basement membrane assembly, promotes cell attachment and angiogenesis, induces neurite outgrowth, affects gene expression and is involved in cell proliferation, migration and differentiation. [2]
  • Laminin promotes tumor cell invasion by induction of proteases that degrade various components of the extracellular matrix. [2]
  • MAPK are involved in laminin signaling. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation
      • metabolism
        • cell metabolism

        Chemical classification

        Composition

        subunit alpha-2

        Sequence
        QRPQQQRQS QAHQQRGLF PAVLNLASN 
        ALITTNATC GEKGPEMYC KLVEHVPGQ 
        PVRNPQCRI CNQNSSNPN QRHPITNAI 
        DGKNTWWQS PSIKNGIEY HYVTITLDL 
        QQVFQIAYV IVKAANSPR PGNWILERS 
        LDDVEYKPW QYHAVTDTE CLTLYNIYP 
        RTGPPSYAK DDEVICTSF YSKIHPLEN 
        GEIHISLIN GRPSADDPS PELLEFTSA 
        RYIRLRFQR IRTLNADLM MFAHKDPRE 
        IDPIVTRRY YYSVKDISV GGMCICYGH 
        ARACPLDPA TNKSRCECE HNTCGDSCD 
        QCCPGFHQK PWRAGTFLT KTECEACNC 
        HGKAEECYY DENVARRNL SLNIRGKYI 
        GGGVCINCT QNTAGINCE TCTDGFFRP 
        KGVSPNYPR PCQPCHCDP IGSLNEVCV 
        KDEKHARRG LAPGSCHCK TGFGGVSCD 
        RCARGYTGY PDCKACNCS GLGSKNEDP 
        CFGPCICKE NVEGGDCSR CKSGFFNLQ 
        EDNWKGCDE CFCSGVSNR CQSSYWTYG 
        KIQDMSGWY LTDLPGRIR VAPQQDDLD 
        SPQQISISN AEARQALPH SYYWSAPAP 
        YLGNKLPAV GGQLTFTIS YDLEEEEED 
        TERVLQLMI ILEGNDLSI STAQDEVYL 
        HPSEEHTNV LLLKEESFT IHGTHFPVR 
        RKEFMTVLA NLKRVLLQI TYSFGMDAI 
        FRLSSVNLE SAVSYPTDG SIAAAVEVC 
        QCPPGYTGS SCESCWPRH RRVNGTIFG 
        GICEPCQCF GHAESCDDV TGECLNCKD 
        HTGGPYCDK CLPGFYGEP TKGTSEDCQ 
        PCACPLNIP SNNFSPTCH LDRSLGLIC 
        DGCPVGYTG PRCERCAEG YFGQPSVPG 
        GSCQPCQCN DNLDFSIPG SCDSLSGSC 
        LICKPGTTG RYCELCADG YFGDAVDAK 
        NCQPCRCNA GGSFSEVCH SQTGQCECR 
        ANVQGQRCD KCKAGTFGL QSARGCVPC 
        NCNSFGSKS FDCEESGQC WCQPGVTGK 
        KCDRCAHGY FNFQEGGCT ACECSHLGN 
        NCDPKTGRC ICPPNTIGE KCSKCAPNT 
        WGHSITTGC KACNCSTVG SLDFQCNVN 
        TGQCNCHPK FSGAKCTEC SRGHWNYPR 
        CNLCDCFLP GTDATTCDS ETKKCSCSD 
        QTGQCTCKV NVEGIHCDR CRPGKFGLD 
        AKNPLGCSS CYCFGTTTQ CSEAKGLIR 
        TWVTLKAEQ TILPLVDEA LQHTTTKGI 
        VFQHPEIVA HMDLMREDL HLEPFYWKL 
        PEQFEGKKL MAYGGKLKY AIYFEAREE 
        TGFSTYNPQ VIIRGGTPT HARIIVRHM 
        AAPLIGQLT RHEIEMTEK EWKYYGDDP 
        RVHRTVTRE DFLDILYDI HYILIKATY 
        GNFMRQSRI SEISMEVAE QGRGTTMTP 
        PADLIEKCD CPLGYSGLS CEACLPGFY 
        RLRSQPGGR TPGPTLGTC VPCQCNGHS 
        SLCDPETSI CQNCQHHTA GDFCERCAL 
        GYYGIVKGL PNDCQQCAC PLISSSNNF 
        SPSCVAEGL DDYRCTACP RGYEGQYCE 
        RCAPGYTGS PGNPGGSCQ ECECDPYGS 
        LPVPCDPVT GFCTCRPGA TGRKCDGCK 
        HWHAREGWE CVFCGDECT GLLLGDLAR 
        LEQMVMSIN LTGPLPAPY KMLYGLENM 
        TQELKHLLS PQRAPERLI QLAEGNLNT 
        LVTEMNELL TRATKVTAD GEQTGQDAE 
        RTNTRAKSL GEFIKELAR DAEAVNEKA 
        IKLNETLGT RDEAFERNL EGLQKEIDQ 
        MIKELRRKN LETQKEIAE DELVAAEAL 
        LKKVKKLFG ESRGENEEM EKDLREKLA 
        DYKNKVDDA WDLLREATD KIREANRLF 
        AVNQKNMTA LEKKKEAVE SGKRQIENT 
        LKEGNDILD EANRLADEI NSIIDYVED 
        IQTKLPPMS EELNDKIDD LSQEIKDRK 
        LAEKVSQAE SHAAQLNDS SAVLDGILD 
        EAKNISFNA TAAFKAYSN IKDYIDEAE 
        KVAKEAKDL AHEATKLAT GPRGLLKED 
        AKGCLQKSF RILNEAKKL ANDVKENED 
        HLNGLKTRI ENADARNGD LLRTLNDTL 
        GKLSAIPND TAAKLQAVK DKARQANDT 
        AKDVLAQIT ELHQNLDGL KKNYNKLAD 
        SVAKTNAVV KDPSKNKII ADADATVKN 
        LEQEADRLI DKLKPIKEL EDNLKKNIS 
        EIKELINQA RKQANSIKV SVSSGGDCI 
        RTYKPEIKK GSYNNIVVN VKTAVADNL 
        LFYLGSAKF IDFLAIEMR KGKVSFLWD 
        VGSGVGRVE YPDLTIDDS YWYRIVASR 
        TGRNGTISV RALDGPKAS IVPSTHHST 
        SPPGYTILD VDANAMLFV GGLTGKLKK 
        ADAVRVITF TGCMGETYF DNKPIGLWN 
        FREKEGDCK GCTVSPQVE DSEGTIQFD 
        GEGYALVSR PIRWYPNIS TVMFKFRTF 
        SSSALLMYL ATRDLRDFM SVELTDGHI 
        KVSYDLGSG MASVVSNQN HNDGKWKSF 
        TLSRIQKQA NISIVDIDT NQEENIATS 
        SSGNNFGLD LKADDKIYF GGLPTLRNL 
        SMKARPEVN LKKYSGCLK DIEISRTPY 
        NILSSPDYV GVTKGCSLE NVYTVSFPK 
        PGFVELSPV PIDVGTEIN LSFSTKNES 
        GIILLGSGG TPAPPRRKR RQTGQAYYA 
        ILLNRGRLE VHLSTGART MRKIVIRPE 
        PNLFHDGRE HSVHVERTR GIFTVQVDE 
        NRRYMQNLT VEQPIEVKK LFVGGAPPE 
        FQPSPLRNI PPFEGCIWN LVINSVPMD 
        FARPVSFKN ADIGRCAHQ KLREDEDGA 
        APAEIVIQP EPVPTPAFP TPTPVLTHG 
        PCAAESEPA LLIGSKQFG LSRNSHIAI 
        AFDDTKVKN RLTIELEVR TEAESGLLF 
        YMARINHAD FATVQLRNG LPYFSYDLG 
        SGDTHTMIP TKINDGQWH KIKIMRSKQ 
        EGILYVDGA SNRTISPKK ADILDVVGM 
        LYVGGLPIN YTTRRIGPV TYSIDGCVR 
        NLHMAEAPA DLEQPTSSF HVGTCFANA 
        QRGTYFDGT GFAKAVGGF KVGLDLLVE 
        FEFRTTTTT GVLLGISSQ KMDGMGIEM 
        IDEKLMFHV DNGAGRFTA VYDAGVPGH 
        LCDGQWHKV TANKIKHRI ELTVDGNQV 
        EAQSPNPAS TSADTNDPV FVGGFPDDL 
        KQFGLTTSI PFRGCIRSL KLTKGTGKP 
        LEVNFAKAL ELRGVQPVS CPAN
        UniProt P24043

        subunit beta-2

        Sequence
        QAPAPDVPG CSRGSCYPA TGDLLVGRA 
        DRLTASSTC GLNGPQPYC IVSHLQDEK 
        KCFLCDSRR PFSARDNPH SHRIQNVVT 
        SFAPQRRAA WWQSENGIP AVTIQLDLE 
        AEFHFTHLI MTFKTFRPA AMLVERSAD 
        FGRTWHVYR YFSYDCGAD FPGVPLAPP 
        RHWDDVVCE SRYSEIEPS TEGEVIYRV 
        LDPAIPIPD PYSSRIQNL LKITNLRVN 
        LTRLHTLGD NLLDPRREI REKYYYALY 
        ELVVRGNCF CYGHASECA PAPGAPAHA 
        EGMVHGACI CKHNTRGLN CEQCQDFYR 
        DLPWRPAED GHSHACRKC ECHGHTHSC 
        HFDMAVYLA SGNVSGGVC DGCQHNTAG 
        RHCELCRPF FYRDPTKDL RDPAVCRSC 
        DCDPMGSQD GGRCDSHDD PALGLVSGQ 
        CRCKEHVVG TRCQQCRDG FFGLSISDR 
        LGCRRCQCN ARGTVPGST PCDPNSGSC 
        YCKRLVTGR GCDRCLPGH WGLSHDLLG 
        CRPCDCDVG GALDPQCDE GTGQCHCRQ 
        HMVGRRCEQ VQPGYFRPF LDHLIWEAE 
        DTRGQVLDV VERLVTPGE TPSWTGSGF 
        VRLQEGQTL EFLVASVPK AMDYDLLLR 
        LEPQVPEQW AELELIVQR PGPVPAHSL 
        CGHLVPKDD RIQGTLQPH ARYLIFPNP 
        VCLEPGISY KLHLKLVRT GGSAQPETP 
        YSGPGLLID SLVLLPRVL VLEMFSGGD 
        AAALERQAT FERYQCHEE GLVPSKTSP 
        SEACAPLLI SLSTLIYNG ALPCQCNPQ 
        GSLSSECNP HGGQCLCKP GVVGRRCDL 
        CAPGYYGFG PTGCQACQC SHEGALSSL 
        CEKTSGQCL CRTGAFGLR CDRCQRGQW 
        GFPSCRPCV CNGHADECN THTGACLGC 
        RDHTGGEHC ERCIAGFHG DPRLPYGGQ 
        CRPCPCPEG PGSQRHFAT SCHQDEYSQ 
        QIVCHCRAG YTGLRCEAC APGHFGDPS 
        RPGGRCQLC ECSGNIDPM DPDACDPHT 
        GQCLRCLHH TEGPHCAHC KPGFHGQAA 
        RQSCHRCTC NLLGTNPQQ CPSPDQCHC 
        DPSSGQCPC LPNVQGPSC DRCAPNFWN 
        LTSGHGCQP CACHPSRAR GPTCNEFTG 
        QCHCRAGFG GRTCSECQE LHWGDPGLQ 
        CHACDCDSR GIDTPQCHR FTGHCSCRP 
        GVSGVRCDQ CARGFSGIF PACHPCHAC 
        FGDWDRVVQ DLAARTQRL EQRAQELQQ 
        TGVLGAFES SFWHMQEKL GIVQGIVGA 
        RNTSAASTA QLVEATEEL RREIGEATE 
        HLTQLEADL TDVQDENFN ANHALSGLE 
        RDRLALNLT LRQLDQHLD LLKHSNFLG 
        AYDSIRHAH SQSAEAERR ANTSALAVP 
        SPVSNSASA RHRTEALMD AQKEDFNSK 
        HMANQRALG KLSAHTHTL SLTDINELV 
        CGAPGDAPC ATSPCGGAG CRDEDGQPR 
        CGGLSCNGA AATADLALG RARHTQAEL 
        QRALAEGGS ILSRVAETR RQASEAQQR 
        AQAALDKAN ASRGQVEQA NQELQELIQ 
        SVKDFLNQE GADPDSIEM VATRVLELS 
        IPASAEQIQ HLAGAIAER VRSLADVDA 
        ILARTVGDV RRAEQLLQD ARRARSWAE 
        DEKQKAETV QAALEEAQR AQGIAQGAI 
        RGAVADTRD TEQTLYQVQ ERMAGAERA 
        LSSAGERAR QLDALLEAL KLKRAGNSL 
        AASTAEETA GSAQGRAQE AEQLLRGPL 
        GDQYQTVKA LAERKAQGV LAAQARAEQ 
        LRDEARDLL QAAQDKLQR LQELEGTYE 
        ENERALESK AAQLDGLEA RMRSVLQAI 
        NLQVQIYNT CQ
        UniProt P55268

        subunit gamma-1

        Sequence
        QAAMDECTD EGGRPQRCM PEFVNAAFN 
        VTVVATNTC GTPPEEYCV QTGVTGVTK 
        SCHLCDAGQ PHLQHGAAF LTDYNNQAD 
        TTWWQSQTM LAGVQYPSS INLTLHLGK 
        AFDITYVRL KFHTSRPES FAIYKRTRE 
        DGPWIPYQY YSGSCENTY SKANRGFIR 
        TGGDEQQAL CTDEFSDIS PLTGGNVAF 
        STLEGRPSA YNFDNSPVL QEWVTATDI 
        RVTLNRLNT FGDEVFNDP KVLKSYYYA 
        ISDFAVGGR CKCNGHASE CMKNEFDKL 
        VCNCKHNTY GVDCEKCLP FFNDRPWRR 
        ATAESASEC LPCDCNGRS QECYFDPEL 
        YRSTGHGGH CTNCQDNTD GAHCERCRE 
        NFFRLGNNE ACSSCHCSP VGSLSTQCD 
        SYGRCSCKP GVMGDKCDR CQPGFHSLT 
        EAGCRPCSC DPSGSIDEC NIETGRCVC 
        KDNVEGFNC ERCKPGFFN LESSNPRGC 
        TPCFCFGHS SVCTNAVGY SVYSISSTF 
        QIDEDGWRA EQRDGSEAS LEWSSERQD 
        IAVISDSYF PRYFIAPAK FLGKQVLSY 
        GQNLSFSFR VDRRDTRLS AEDLVLEGA 
        GLRVSVPLI AQGNSYPSE TTVKYVFRL 
        HEATDYPWR PALTPFEFQ KLLNNLTSI 
        KIRGTYSER SAGYLDDVT LASARPGPG 
        VPATWVESC TCPVGYGGQ FCEMCLSGY 
        RRETPNLGP YSPCVLCAC NGHSETCDP 
        ETGVCNCRD NTAGPHCEK CSDGYYGDS 
        TAGTSSDCQ PCPCPGGSS CAVVPKTKE 
        VVCTNCPTG TTGKRCELC DDGYFGDPL 
        GRNGPVRLC RLCQCSDNI DPNAVGNCN 
        RLTGECLKC IYNTAGFYC DRCKDGFFG 
        NPLAPNPAD KCKACNCNL YGTMKQQSS 
        CNPVTGQCE CLPHVTGQD CGACDPGFY 
        NLQSGQGCE RCDCHALGS TNGQCDIRT 
        GQCECQPGI TGQHCERCE VNHFGFGPE 
        GCKPCDCHP EGSLSLQCK DDGRCECRE 
        GFVGNRCDQ CEENYFYNR SWPGCQECP 
        ACYRLVKDK VADHRVKLQ ELESLIANL 
        GTGDEMVTD QAFEDRLKE AEREVMDLL 
        REAQDVKDV DQNLMDRLQ RVNNTLSSQ 
        ISRLQNIRN TIEETGNLA EQARAHVEN 
        TERLIEIAS RELEKAKVA AANVSVTQP 
        ESTGDPNNM TLLAEEARK LAERHKQEA 
        DDIVRVAKT ANDTSTEAY NLLLRTLAG 
        ENQTAFEIE ELNRKYEQA KNISQDLEK 
        QAARVHEEA KRAGDKAVE IYASVAQLS 
        PLDSETLEN EANNIKMEA ENLEQLIDQ 
        KLKDYEDLR EDMRGKELE VKNLLEKGK 
        TEQQTADQL LARADAAKA LAEEAAKKG 
        RDTLQEAND ILNNLKDFD RRVNDNKTA 
        AEEALRKIP AINQTITEA NEKTREAQQ 
        ALGSAAADA TEAKNKAHE AERIASAVQ 
        KNATSTKAE AERTFAEVT DLDNEVNNM 
        LKQLQEAEK ELKRKQDDA DQDMMMAGM 
        ASQAAQEAE INARKAKNS VTSLLSIIN 
        DLLEQLGQL DTVDLNKLN EIEGTLNKA 
        KDEMKVSDL DRKVSDLEN EAKKQEAAI 
        MDYNRDIEE IMKDIRNLE DIRKTLPSG 
        CFNTPSIEK P
        UniProt P11047

        Links to other resources

          Targets

          Cellagrindystroglycanintegrin alpha-1/beta-1integrin alpha-2/beta-1integrin alpha-6/beta-1integrin alpha-7/beta-1
          beta cell of islet of Langerhans Present
          Influences
          • insulin
          oligodendrocyte Present
          Reference