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Details for messenger / hormone: laminin-8

EndoNet ID: ENH00832

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Synonyms

  • laminin-8
  • laminin alpha-4/beta-1/gamma-1

General information

  • Laminin is essential for basement membrane assembly, promotes cell attachment and angiogenesis, induces neurite outgrowth, affects gene expression and is involved in cell proliferation, migration and differentiation. [1]
  • Laminin promotes tumor cell invasion by induction of proteases that degrade various components of the extracellular matrix. [1]
  • MAPK are involved in laminin signaling. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation
      • metabolism
        • cell metabolism

        Chemical classification

        Composition

        subunit alpha-4

        Sequence
        AASGDDNAF PFDIEGSSA VGRQDPPET 
        SEPRVALGR LPPAAEKCN AGFFHTLSG 
        ECVPCDCNG NSNECLDGS GYCVHCQRN 
        TTGEHCEKC LDGYIGDSI RGAPQFCQP 
        CPCPLPHLA NFAESCYRK NGAVRCICN 
        ENYAGPNCE RCAPGYYGN PLLIGSTCK 
        KCDCSGNSD PNLIFEDCD EVTGQCRNC 
        LRNTTGFKC ERCAPGYYG DARIAKNCA 
        VCNCGGGPC DSVTGECLE EGFEPPTGM 
        DCPTISCDK CVWDLTDAL RLAALSIEE 
        GKSGVLSVS SGAAAHRHV NEINATIYL 
        LKTKLSERE NQYALRKIQ INNAENTMK 
        SLLSDVEEL VEKENQASR KGQLVQKES 
        MDTINHASQ LVEQAHDMR DKIQEINNK 
        MLYYGEEHE LSPKEISEK LVLAQKMLE 
        EIRSRQPFF TQRELVDEE ADEAYELLS 
        QAESWQRLH NETRTLFPV VLEQLDDYN 
        AKLSDLQEA LDQALNYVR DAEDMNRAT 
        AARQRDHEK QQERVREQM EVVNMSLST 
        SADSLTTPR LTLSELDDI IKNASGIYA 
        EIDGAKSEL QVKLSNLSN LSHDLVQEA 
        IDHAQDLQQ EANELSRKL HSSDMNGLV 
        QKALDASNV YENIVNYVS EANETAEFA 
        LNTTDRIYD AVSGIDTQI IYHKDESEN 
        LLNQARELQ AKAESSSDE AVADTSRRV 
        GGALARKSA LKTRLSDAV KQLQAAERG 
        DAQQRLGQS RLITEEANR TTMEVQQAT 
        APMANNLTN WSQNLQHFD SSAYNTAVN 
        SARDAVRNL TEVVPQLLD QLRTVEQKR 
        PASNVSASI QRIRELIAQ TRSVASKIQ 
        VSMMFDGQS AVEVHSRTS MDDLKAFTS 
        LSLYMKPPV KRPELTETA DQFILYLGS 
        KNAKKEYMG LAIKNDNLV YVYNLGTKD 
        VEIPLDSKP VSSWPAYFS IVKIERVGK 
        HGKVFLTVP SLSSTAEEK FIKKGEFSG 
        DDSLLDLDP EDTVFYVGG VPSNFKLPT 
        SLNLPGFVG CLELATLNN DVISLYNFK 
        HIYNMDPST SVPCARDKL AFTQSRAAS 
        YFFDGSGYA VVRDITRRG KFGQVTRFD 
        IEVRTPADN GLILLMVNG SMFFRLEMR 
        NGYLHVFYD FGFSGGPVH LEDTLKKAQ 
        INDAKYHEI SIIYHNDKK MILVVDRRH 
        VKSMDNEKM KIPFTDIYI GGAPPEILQ 
        SRALRAHLP LDINFRGCM KGFQFQKKD 
        FNLLEQTET LGVGYGCPE DSLISRRAY 
        FNGQSFIAS IQKISFFDG FEGGFNFRT 
        LQPNGLLFY YASGSDVFS ISLDNGTVI 
        MDVKGIKVQ SVDKQYNDG LSHFVISSV 
        SPTRYELIV DKSRVGSKN PTKGKIEQT 
        QASEKKFYF GGSPISAQY ANFTGCISN 
        AYFTRVDRD VEVEDFQRY TEKVHTSLY 
        ECPIESSPL FLLHKKGKN LSKPKASQN 
        KKGGKSKDA PSWDPVALK LPERNTPRN 
        SHCHLSNSP RAIEHAYQY GGTANSRQE 
        FEHLKGDFG AKSQFSIRL RTRSSHGMI 
        FYVSDQEEN DFMTLFLAH GRLVYMFNV 
        GHKKLKIRS QEKYNDGLW HDVIFIRER 
        SSGRLVIDG LRVLEESLP PTEATWKIK 
        GPIYLGGVA PGKAVKNVQ INSIYSFSG 
        CLSNLQLNG ASITSASQT FSVTPCFEG 
        PMETGTYFS TEGGYVVLD ESFNIGLKF 
        EIAFEVRPR SSSGTLVHG HSVNGEYLN 
        VHMKNGQVI VKVNNGIRD FSTSVTPKQ 
        SLCDGRWHR ITVIRDSNV VQLDVDSEV 
        NHVVGPLNP KPIDHREPV FVGGVPESL 
        LTPRLAPSK PFTGCIRHF VIDGHPVSF 
        SKAALVSGA VSINSCPAA
        UniProt Q16363

        subunit beta-1

        Sequence
        QEPEFSYGC AEGSCYPAT GDLLIGRAQ 
        KLSVTSTCG LHKPEPYCI VSHLQEDKK 
        CFICNSQDP YHETLNPDS HLIENVVTT 
        FAPNRLKIW WQSENGVEN VTIQLDLEA 
        EFHFTHLIM TFKTFRPAA MLIERSSDF 
        GKTWGVYRY FAYDCEASF PGISTGPMK 
        KVDDIICDS RYSDIEPST EGEVIFRAL 
        DPAFKIEDP YSPRIQNLL KITNLRIKF 
        VKLHTLGDN LLDSRMEIR EKYYYAVYD 
        MVVRGNCFC YGHASECAP VDGFNEEVE 
        GMVHGHCMC RHNTKGLNC ELCMDFYHD 
        LPWRPAEGR NSNACKKCN CNEHSISCH 
        FDMAVYLAT GNVSGGVCD DCQHNTMGR 
        NCEQCKPFY YQHPERDIR DPNFCERCT 
        CDPAGSQNE GICDSYTDF STGLIAGQC 
        RCKLNVEGE HCDVCKEGF YDLSSEDPF 
        GCKSCACNP LGTIPGGNP CDSETGHCY 
        CKRLVTGQH CDQCLPEHW GLSNDLDGC 
        RPCDCDLGG ALNNSCFAE SGQCSCRPH 
        MIGRQCNEV EPGYYFATL DHYLYEAEE 
        ANLGPGVSI VERQYIQDR IPSWTGAGF 
        VRVPEGAYL EFFIDNIPY SMEYDILIR 
        YEPQLPDHW EKAVITVQR PGRIPTSSR 
        CGNTIPDDD NQVVSLSPG SRYVVLPRP 
        VCFEKGTNY TVRLELPQY TSSDSDVES 
        PYTLIDSLV LMPYCKSLD IFTVGGSGD 
        GVVTNSAWE TFQRYRCLE NSRSVVKTP 
        MTDVCRNII FSISALLHQ TGLACECDP 
        QGSLSSVCD PNGGQCQCR PNVVGRTCN 
        RCAPGTFGF GPSGCKPCE CHLQGSVNA 
        FCNPVTGQC HCFQGVYAR QCDRCLPGH 
        WGFPSCQPC QCNGHADDC DPVTGECLN 
        CQDYTMGHN CERCLAGYY GDPIIGSGD 
        HCRPCPCPD GPDSGRQFA RSCYQDPVT 
        LQLACVCDP GYIGSRCDD CASGYFGNP 
        SEVGGSCQP CQCHNNIDT TDPEACDKE 
        TGRCLKCLY HTEGEHCQF CRFGYYGDA 
        LQQDCRKCV CNYLGTVQE HCNGSDCQC 
        DKATGQCLC LPNVIGQNC DRCAPNTWQ 
        LASGTGCDP CNCNAAHSF GPSCNEFTG 
        QCQCMPGFG GRTCSECQE LFWGDPDVE 
        CRACDCDPR GIETPQCDQ STGQCVCVE 
        GVEGPRCDK CTRGYSGVF PDCTPCHQC 
        FALWDVIIA ELTNRTHRF LEKAKALKI 
        SGVIGPYRE TVDSVERKV SEIKDILAQ 
        SPAAEPLKN IGNLFEEAE KLIKDVTEM 
        MAQVEVKLS DTTSQSNST AKELDSLQT 
        EAESLDNTV KELAEQLEF IKNSDIRGA 
        LDSITKYFQ MSLEAEERV NASTTEPNS 
        TVEQSALMR DRVEDVMME RESQFKEKQ 
        EEQARLLDE LAGKLQSLD LSAAAEMTC 
        GTPPGASCS ETECGGPNC RTDEGERKC 
        GGPGCGGLV TVAHNAWQK AMDLDQDVL 
        SALAEVEQL SKMVSEAKL RADEAKQSA 
        EDILLKTNA TKEKMDKSN EELRNLIKQ 
        IRNFLTQDS ADLDSIEAV ANEVLKMEM 
        PSTPQQLQN LTEDIRERV ESLSQVEVI 
        LQHSAADIA RAEMLLEEA KRASKSATD 
        VKVTADMVK EALEEAEKA QVAAEKAIK 
        QADEDIQGT QNLLTSIES ETAASEETL 
        FNASQRISE LERNVEELK RKAAQNSGE 
        AEYIEKVVY TVKQSAEDV KKTLDGELD 
        EKYKKVENL IAKKTEESA DARRKAEML 
        QNEAKTLLA QANSKLQLL KDLERKYED 
        NQRYLEDKA QELARLEGE VRSLLKDIS 
        QKVAVYSTC L
        UniProt P07942

        subunit gamma-1

        Sequence
        QAAMDECTD EGGRPQRCM PEFVNAAFN 
        VTVVATNTC GTPPEEYCV QTGVTGVTK 
        SCHLCDAGQ PHLQHGAAF LTDYNNQAD 
        TTWWQSQTM LAGVQYPSS INLTLHLGK 
        AFDITYVRL KFHTSRPES FAIYKRTRE 
        DGPWIPYQY YSGSCENTY SKANRGFIR 
        TGGDEQQAL CTDEFSDIS PLTGGNVAF 
        STLEGRPSA YNFDNSPVL QEWVTATDI 
        RVTLNRLNT FGDEVFNDP KVLKSYYYA 
        ISDFAVGGR CKCNGHASE CMKNEFDKL 
        VCNCKHNTY GVDCEKCLP FFNDRPWRR 
        ATAESASEC LPCDCNGRS QECYFDPEL 
        YRSTGHGGH CTNCQDNTD GAHCERCRE 
        NFFRLGNNE ACSSCHCSP VGSLSTQCD 
        SYGRCSCKP GVMGDKCDR CQPGFHSLT 
        EAGCRPCSC DPSGSIDEC NIETGRCVC 
        KDNVEGFNC ERCKPGFFN LESSNPRGC 
        TPCFCFGHS SVCTNAVGY SVYSISSTF 
        QIDEDGWRA EQRDGSEAS LEWSSERQD 
        IAVISDSYF PRYFIAPAK FLGKQVLSY 
        GQNLSFSFR VDRRDTRLS AEDLVLEGA 
        GLRVSVPLI AQGNSYPSE TTVKYVFRL 
        HEATDYPWR PALTPFEFQ KLLNNLTSI 
        KIRGTYSER SAGYLDDVT LASARPGPG 
        VPATWVESC TCPVGYGGQ FCEMCLSGY 
        RRETPNLGP YSPCVLCAC NGHSETCDP 
        ETGVCNCRD NTAGPHCEK CSDGYYGDS 
        TAGTSSDCQ PCPCPGGSS CAVVPKTKE 
        VVCTNCPTG TTGKRCELC DDGYFGDPL 
        GRNGPVRLC RLCQCSDNI DPNAVGNCN 
        RLTGECLKC IYNTAGFYC DRCKDGFFG 
        NPLAPNPAD KCKACNCNL YGTMKQQSS 
        CNPVTGQCE CLPHVTGQD CGACDPGFY 
        NLQSGQGCE RCDCHALGS TNGQCDIRT 
        GQCECQPGI TGQHCERCE VNHFGFGPE 
        GCKPCDCHP EGSLSLQCK DDGRCECRE 
        GFVGNRCDQ CEENYFYNR SWPGCQECP 
        ACYRLVKDK VADHRVKLQ ELESLIANL 
        GTGDEMVTD QAFEDRLKE AEREVMDLL 
        REAQDVKDV DQNLMDRLQ RVNNTLSSQ 
        ISRLQNIRN TIEETGNLA EQARAHVEN 
        TERLIEIAS RELEKAKVA AANVSVTQP 
        ESTGDPNNM TLLAEEARK LAERHKQEA 
        DDIVRVAKT ANDTSTEAY NLLLRTLAG 
        ENQTAFEIE ELNRKYEQA KNISQDLEK 
        QAARVHEEA KRAGDKAVE IYASVAQLS 
        PLDSETLEN EANNIKMEA ENLEQLIDQ 
        KLKDYEDLR EDMRGKELE VKNLLEKGK 
        TEQQTADQL LARADAAKA LAEEAAKKG 
        RDTLQEAND ILNNLKDFD RRVNDNKTA 
        AEEALRKIP AINQTITEA NEKTREAQQ 
        ALGSAAADA TEAKNKAHE AERIASAVQ 
        KNATSTKAE AERTFAEVT DLDNEVNNM 
        LKQLQEAEK ELKRKQDDA DQDMMMAGM 
        ASQAAQEAE INARKAKNS VTSLLSIIN 
        DLLEQLGQL DTVDLNKLN EIEGTLNKA 
        KDEMKVSDL DRKVSDLEN EAKKQEAAI 
        MDYNRDIEE IMKDIRNLE DIRKTLPSG 
        CFNTPSIEK P
        UniProt P11047

        Links to other resources

          Targets

          Cellintegrin alpha-3/beta-1integrin alpha-6/beta-1integrin alpha-7/beta-1
          keratinocyte Present
          oligodendrocyte Present
          smooth muscle cell Present
          Phenotypes
          • smooth muscle cell migration
          Reference