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Details for messenger / hormone: tumstatin

EndoNet ID: ENH00838

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Synonyms

  • goodpasture antigen
  • collagen alpha-3(IV) chain
  • tumstatin
  • NC1 domain of alpha3 chain of type IV collagen
  • alpha 3(IV)NC1

General information

  • Antiangiogenic protein released by limited proteolysis from type IV collagen. [1]
  • Tumstatin prevents angiogenesis via inhibition of endothelial cell proliferation and promotion of apoptosis with no effect on migration, whereas human endostatin prevents endothelial cell migration with no effect on proliferation. [2]
  • Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. [3]
  • Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth. [4]
  • Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic and proapoptotic activity. [5]
  • NC1 domain of alpha3 chain of type IV collagen. [6]
  • Through a requisite interaction with alphaVbeta3 integrin, tumstatin inhibits activation of focal adhesion kinase (FAK), phosphatidylinositol 3-kinase (PI3-kinase), protein kinase B (PKB/Akt), and mammalian target of rapamycin (mTOR), and it prevents the dissociation of eukaryotic initiation factor 4E protein (eIF4E) from 4E-binding protein 1. [5]
  • Tumstatin functions as an endothelial cell-specific inhibitor of protein synthesis. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • growth inhibition
        • apoptosis

        Chemical classification

        Links to other resources

        UniProt Q9NYC4
        Ensembl ENST00000396578
        KEGG hsa:1285

          Targets

          Cellintegrin alphaV/beta3
          endothelial cell Present
          Phenotypes
          • endothelial cell adhesion
          • positive regulation of endothelial cell migration
          Reference