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Details for messenger / hormone: netrin-4

EndoNet ID: ENH00843

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Synonyms

  • beta-netrin
  • hepar-derived netrin-like protein
  • NTN4
  • beta netrin
  • netrin 4
  • netrin-4

General information

  • Beta-netrin is homologous to the NH(2) terminus of laminin chain short arms; it contains a laminin-like domain VI and 3.5 laminin EGF repeats and a netrin C domain. Unlike other netrins, this new netrin is more related to the laminin beta chains, thus, its name beta-netrin. [1]
  • Beta-netrin promotes neurite elongation from olfactory bulb explants. [1]
  • Beta-netrin is important in neural, kidney, and vascular development. [1]
  • Netrin-4 promotes cortical axon outgrowth. [2]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    • Netrin-4 contains three known domains: LNT, EGFL and NCT. [2]

    Links to other resources

    UniProt Q9HB63
    Ensembl ENST00000343702
    KEGG hsa:59277
    • Anatomical structure: floor_plate_of_neural_tube

    Targets

    CellDCCnetrin receptor UNC5A
    No records found.
    Reference