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Details for messenger / hormone: IGFBP-1 isoform a

EndoNet ID: ENH00859

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Synonyms

  • IGFBP1
  • IGF-binding protein 1 isoform a
  • placental protein 12
  • PP12
  • IBP-1
  • insulin-like growth factor-binding protein 1
  • IGFBP-1 isoform a
  • insulin-like growth factor-binding protein 1 isoform a

General information

  • Its production is stimulated by TNF alpha, IL-1 beta and IL-6.
  • IGFBP-1 inhibits breast cancer cell motility. [1]
  • Progesterone inhibits IGFBP-1 production by explants of the Fallopian tube. [2]
  • Reduced IGFBP-1 is associated with thickening of the carotid wall in type 2 diabetes. [3]
  • Glucagon and GPL-1 have a post-transcriptional stimulatory effect on IGFBP-1 release. [4]
  • Binds equally well IGF1 and IGF2. [5]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • IGFBP family

      Composition

      Sequence
      APWQCAPCS AEKLALCPP VSASCSEVT 
      RSAGCGCCP MCALPLGAA CGVATARCA 
      RGLSCRALP GEQQPLHAL TRGQGACVQ 
      ESDASAPHA AEAGSPESP ESTEITEEE 
      LLDNFHLMA PSEEDHSIL WDAISTYDG 
      SKALHVTNI KKWKEPCRI ELYRVVESL 
      AKAQETSGE EISKFYLPN CNKNGFYHS 
      RQCETSMDG EAGLCWCVY PWNGKRIPG 
      SPEIRGDPN CQIYFNVQN

      IGF binding protein 1 isoform a, mature peptide

      Sequence
      APWQCAPCS AEKLALCPP VSASCSEVT 
      RSAGCGCCP MCALPLGAA CGVATARCA 
      RGLSCRALP GEQQPLHAL TRGQGACVQ 
      ESDASAPHA AEAGSPESP ESTEITEEE 
      LLDNFHLMA PSEEDHSIL WDAISTYDG 
      SKALHVTNI KKWKEPCRI ELYRVVESL 
      AKAQETSGE EISKFYLPN CNKNGFYHS 
      RQCETSMDG EAGLCWCVY PWNGKRIPG 
      SPEIRGDPN CQIYFNVQN

      Links to other resources

      UniProt P08833
      Ensembl ENSG00000146678
      KEGG hsa:3484
      • Anatomical structure: hepatocyte

        • Hepatocytes have been shown to express IGFBP-1 through IGFBP-4 mRNAs and release the corresponding proteins. [6]

      Targets

      Cell
      No records found.
      Reference