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Details for messenger / hormone: neuregulin 1 isoform SMDF

EndoNet ID: ENH00861

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Synonyms

  • neuregulin-1, sensory and motor neuron-derived factor isoform
  • glial growth factor
  • sensory and motor neuron-derived factor
  • acetylcholine receptor-inducing activity
  • breast cancer cell differentiation factor p45
  • Heregulin
  • neu differentiation factor
  • pro-neuregulin-1, membrane-bound isoform
  • neuregulin 1 isoform SMDF
  • NRG1-SMDF

General information

  • NRG1 is implicated in the aetiology of breast cancer, heart disease, multiple sclerosis and schizophrenia. [1]
  • Neuregulin 1 growth factors regulate proliferation but not apoptosis of a CNS neuronal progenitor cell line. [2]
  • NRG1 is a ligand for ErbB tyrosine kinase receptors. [1]
  • NRG1-mediated signalling results in stimulation or inhibition of cell proliferation, apoptosis, migration, differentiation and adhesion. [1]
  • SMDF is a member of the neuregulin family of proteins structurally characterized by a novel N-terminal domain. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • growth inhibition
        • apoptosis

        Chemical classification

        • hormone
          • genome-encoded
            • cytokines
              • neuregulin-family

          Composition

          Sequence 
          MEIYSPDMS EVAAERSSS PSTQLSADP 
SLDGLPAAE DMPEPQTED GRTPGLVGL 
AVPCCACLE AERLRGCLN SEKICIVPI 
LACLVSLCL CIAGLKWVF VDKIFEYDS 
PTHLDPGGL GQDPIISLD ATAASAVWV 
SSEAYTSPV SRAQSESEV QVTVQGDKA 
VVSFEPSAA PTPKNRIFA FSFLPSTAP 
SFPSPTRNP EVRTPKSAT QPQTTETNL 
QTAPKLSTS TSTTGTSHL VKCAEKEKT 
FCVNGGECF MVKDLSNPS RYLCKCPNE 
FTGDRCQNY VMASFYSTS TPFLSLPE

          Links to other resources

          UniProt Q15491-1
          Ensembl ENST00000287840
          KEGG hsa:3084

            Targets

            CellErbB3ErbB4
            No records found.
            Reference