Status
Please wait ...

Details for messenger / hormone: neuregulin 1 isoform GGF2

EndoNet ID: ENH00862

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • NRG1-GGF2
  • neuregulin-1, glial growth factor 2
  • GGF2
  • glial growth factor 2
  • neuregulin 1 isoform GGF2
  • glial growth factor
  • sensory and motor neuron-derived factor
  • acetylcholine receptor-inducing activity
  • breast cancer cell differentiation factor p45
  • Heregulin
  • neu differentiation factor
  • pro-neuregulin-1, membrane-bound isoform

General information

  • Isoform 9 is the major form in skeletal muscle cells, in the nervous system it is expressed in spinal cord and brain. [1]
  • The mechanism of GGF's protective effect may be related to its direct action on Schwann cells, stimulating their mitosis as well as inducing neurotrophic factors essential to neuronal maintenance and repair. [2]
  • NRG1 is implicated in the aetiology of breast cancer, heart disease, multiple sclerosis and schizophrenia. [3]
  • NRG1 is a ligand for ErbB tyrosine kinase receptors. [3]
  • NRG1-mediated signalling results in stimulation or inhibition of cell proliferation, apoptosis, migration, differentiation and adhesion. [3]
  • Glial growth factors are proteins encoded by the neuregulin gene and are thought to signal via receptor tyrosine kinases. [4]
  • GGF2 is a neuronal signal that promotes the proliferation and survival of the oligodendrocyte, the myelinating cell of the central nervous system. [5]
  • GGF2 is neurotrophic and neuroprotective for developing dopaminergic neurons and may play a role in repair of the damaged nigrostriatal system that occurs in Parkinson's disease. [6]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • growth inhibition
        • apoptosis

        Chemical classification

        • hormone
          • genome-encoded
            • cytokines
              • neuregulin-family

          Composition

          isoform 9, sequence

          Sequence 
          MRWRRAPRR SGRPGPRAQ RPGSAARSS 
PPLPLLPLL LLLGTAALA PGAAAGNEA 
APAGASVCY SSPPSVGSV QELAQRAAV 
VIEGKVHPQ RRQQGALDR KAAAAAGEA 
GAWGGDREP PAAGPRALG PPAEEPLLA 
ANGTVPSWP TAPVPSAGE PGEEAPYLV 
KVHQVWAVK AGGLKKDSL LTVRLGTWG 
HPAFPSCGR LKEDSRYIF FMEPDANST 
SRAPAAFRA SFPPLETGR NLKKEVSRV 
LCKRCALPP RLKEMKSQE SAAGSKLVL 
RCETSSEYS SLRFKWFKN GNELNRKNK 
PQNIKIQKK PGKSELRIN KASLADSGE 
YMCKVISKL GNDSASANI TIVESNATS 
TSTTGTSHL VKCAEKEKT FCVNGGECF 
MVKDLSNPS RYLCKCPNE FTGDRCQNY 
VMASFYSTS TPFLSLPE

          Links to other resources

          UniProt Q02297-9
          Ensembl ENST00000287840
          KEGG hsa:3084

          • Anatomical structure: skeleton_muscle

          • Anatomical structure: spinal_cord

          • Anatomical structure: brain

          Targets

          CellErbB2
          No records found.
          Reference