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Details for messenger / hormone: ECM1a

EndoNet ID: ENH00868

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Synonyms

  • ECM1a
  • secretory component p85
  • extracellular matrix protein 1
  • ECM1-1
  • extracellular matrix protein 1 full length isoform
  • secretory component p85 isoform 1
  • extracellular matrix protein 1 isoform 1

General information

  • Extracellular matrix protein 1, an approximately 85-kDa glycoprotein with broad tissue distribution, harbors mutations in lipoid proteinosis, a heritable disease characterized by reduplication of basement membranes and hyalinization of dermis, associated with neurologic disorders. [1]
  • ECM1 tends to be preferentially expressed by metastatic epithelial tumors. [2]
  • Both the ECM1a and ECM1b isoforms are able to stimulate blood vessel endothelial cell proliferation, and to promote angiogenesis. [3]
  • Expression of ECM1 in human skin is decreased by age and increased upon ultraviolet exposure. [4]
  • ECM1 interacts with the domain III of fibulin-1C and 1D variants through its central tandem repeat 2. [5]
  • Perlecan protein core interacts with extracellular matrix protein 1, a glycoprotein involved in bone formation and angiogenesis. [6]
  • ECM1 inhibits MMP9 proteolytic activity through high-affinity protein/protein interactions. [1]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • growth stimulation

      Chemical classification

      Composition

      PDGF B-B dimer (2 times)

      Sequence 
      SLGSLTIAE PAMIAECKT RTEVFEISR 
RLIDRTNAN FLVWPPCVE VQRCSGCCN 
NRNVQCRPT QVQLRPVQV RKIEIVRKK 
PIFKKATVT LEDHLACKC ETVAAARPV 
T

      Links to other resources

      UniProt Q16610
      Ensembl ENST00000369047
      KEGG hsa:1893

      • Anatomical structure: blood_vessel

      • Anatomical structure: skin

      • Anatomical structure: tonsil

      • Anatomical structure: placenta

      • Anatomical structure: heart

      • Anatomical structure: basal_layer_of_epidermis

      • Anatomical structure: respiratory_organ

      • Anatomical structure: small_intestine

      • Anatomical structure: ovary

      • Anatomical structure: prostate

      • Anatomical structure: testis

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: pancreas

      • Anatomical structure: kidney

      • Anatomical structure: lung

      Targets

      Cell
      No records found.
      Reference