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Details for messenger / hormone: ADNP

EndoNet ID: ENH00878

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Synonyms

  • activity-dependent neuroprotective protein
  • activity-dependent neuroprotector
  • activity-dependent neuroprotector homeobox protein
  • ADNP

General information

  • ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. [1]
  • Activity-dependent neuroprotective protein (ADNP) is essential for brain formation. [2]

Classification

Hormone function

  • development and growth
    • apoptosis
    • immune response
      • activation

      Chemical classification

      Composition

      NAP

      • NAP was identified as the smallest active element of ADNP exhibiting potent neuroprotective activities. [3]
      • NAP induces neurite outgrowth and protects primary neurons against microtubule-assiciated ZnCl2 toxicity. [3]
      • Tubulin is the target binding-site for NAP-related pepttides: ADNF-9, D-NAP and D-SAL. [3]
      • The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide [3]
      Sequence 
      NAPVSIPQ
      UniProt Q9H2P0

      Activity-dependent neuroprotector homeobox protein

      Sequence 
      MFQLPVNNL GSLRKARKT VKKILSDIG 
LEYCKEHIE DFKQFEPND FYLKNTTWE 
DVGLWDPSL TKNQDYRTK PFCCSACPF 
SSKFFSAYK SHFRNVHSE DFENRILLN 
CPYCTFNAD KKTLETHIK IFHAPNASA 
PSSSLSTFK DKNKNDGLK PKQADSVEQ 
AVYYCKKCT YRDPLYEIV RKHIYREHF 
QHVAAPYIA KAGEKSLNG AVPLGSNAR 
EESSIHCKR CLFMPKSYE ALVQHVIED 
HERIGYQVT AMIGHTNVV VPRSKPLML 
IAPKPQDKK SMGLPPRIG SLASGNVRS 
LPSQQMVNR LSIPKPNLN STGVNMMSS 
VHLQQNNYG VKSVGQGYS VGQSMRLGL 
GGNAPVSIP QQSQSVKQL LPSGNGRSY 
GLGSEQRSQ APARYSLQS ANASSLSSG 
QLKSPSLSQ SQASRVLGQ SSSKPAAAA 
TGPPPGNTS STQKWKICT ICNELFPEN 
VYSVHFEKE HKAEKVPAV ANYIMKIHN 
FTSKCLYCN RYLPTDTLL NHMLIHGLS 
CPYCRSTFN DVEKMAAHM RMVHIDEEM 
GPKTDSTLS FDLTLQQGS HTNIHLLVT 
TYNLRDAPA ESVAYHAQN NPPVPPKPQ 
PKVQEKADI PVKSSPQAA VPYKKDVGK 
TLCPLCFSI LKGPISDAL AHHLRERHQ 
VIQTVHPVE KKLTYKCIH CLGVYTSNM 
TASTITLHL VHCRGVGKT QNGQDKTNA 
PSRLNQSPS LAPVKRTYE QMEFPLLKK 
RKLDDDSDS PSFFEEKPE EPVVLALDP 
KGHEDDSYE ARKSFLTKY FNKQPYPTR 
REIEKLAAS LWLWKSDIA SHFSNKRKK 
CVRDCEKYK PGVLLGFNM KELNKVKHE 
MDFDAEWLF ENHDEKDSR VNASKTADK 
KLNLGKEDD SSSDSFENL EEESNESGS 
PFDPVFEVE PKISNDNPE EHVLKVIPE 
DASESEEKL DQKEDGSKY ETIHLTEEP 
TKLMHNASD SEVDQDDVV EWKDGASPS 
ESGPGSQQV SDFEDNTCE MKPGTWSDE 
SSQSEDARS SKPAAKKKA TMQGDREQL 
KWKNSSYGK VEGFWSKDQ SQWKNASEN 
DERLSNPQI EWQNSTIDS EDGEQFDNM 
TDGVAEPMH GSLAGVKLS SQQA

      Links to other resources

      UniProt Q9H2P0
      Ensembl ENST00000396032
      KEGG hsa:23394

      • Anatomical structure: astrocyte

        • Furthermore, ADNP-like immunoreactivity was identified in conditioned media from astrocytes, and the concentration increased after treatment with VIP. [4]

      • Anatomical structure: cerebellum

      • Anatomical structure: hippocampus

      • Anatomical structure: medulla_oblongata

      • Anatomical structure: cerebral_cortex

      • Anatomical structure: mesencephalon

      • Anatomical structure: white_matter

      • Anatomical structure: astroglia

      Targets

      Cell
      No records found.
      Reference