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Details for messenger / hormone: humanin

EndoNet ID: ENH00882

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Synonyms

  • humanin
  • HN
  • rescue factor humanin

General information

  • Humanin peptide suppresses apoptosis by interfering with Bax activation. [1]
  • Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity. [2]
  • HN is an IGFBP-3-binding partner. The high affinity interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 may regulate cell survival and apoptosis. [3]
  • Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. [4]
  • Humanin uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. [5]
  • HN is effective in suppressing not only neurotoxicity by Abeta 1-43, V642I-APP, NL-APP, M146L-PS1, and N141I-PS2 but also neurotoxicity by Abeta 1-42/Abeta 25-35, anti-APP antibody, other FAD mutants of APP (A617G-APP and L648P-APP), and other FAD mutants of PS1 (A246E-PS1, L286V-PS1, C410Y-PS1, and H163R-PS1): the neuroprotective function of HN is highly selective for FAD gene-relevant insults. [6]
  • Humanin is an anti-apoptotic peptide which is encoded in the mitochondrial genome. [7]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Composition

    humanin

    • HN possesses a clear structural dependency for its neuroprotective function. The Pro3-Pro19 region acts as a core domain, among which Pro3, Cys8, Leu9, Leu12, Thr13, Ser14, and Pro19 are essential residues; and Cys8 can be substituted to Lys and Arg without impairing the HN action, whereas His substitution significantly but not completely attenuated and any other substitution resulted in a loss of the rescue function of HN. [6]
    Sequence
    MAPRGFSCL LLLTSEIDL PVKRRA
    UniProt Q8IVG9

    Links to other resources

    UniProt Q8IVG9
    Ensembl ENST00000443568
    • Anatomical structure: heart

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: kidney

    • Anatomical structure: brain

    • Anatomical structure: digestive_system

    Targets

    CellFPRL1
    lung Present
    monocyte Present
    Phenotypes
    • monocyte activation
    neutrophil granulocyte Present
    Reference